Cyclin Dependent Kinase 5 (CDK5)


PSSALRE; CDKN5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit;TPKII catalytic subunit

Cyclin Dependent Kinase 5 (CDK5)

Recently Cdk5 has emerged as an essential kinase in sensory pathways. Recent reports of Pareek et al. from NIH suggest its necessity in pain signaling. CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2. Unlike other cyclin dependent kinases, CDK5 does not also require phosphorylation on the T loop so that binding with the activator is sufficient to activate the kinase. Cdk5 is involved in the processes of neuronal maturation and migration, phosphorylating the key intracellular adaptor of the reelin signaling chain.Experiments performed on mice lacking p35, a necessary activator of cdk5 in early brain development, showed that the normal layering of neurons was reversed in the cortex.

Organism species: Homo sapiens (Human)

ProteinsRPA739Hu01Recombinant Cyclin Dependent Kinase 5 (CDK5)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA739Hu01Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC; IP.
LAA739Hu71Biotin-Linked Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC.
LAA739Hu81FITC-Linked Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC; IF.
MAA739Hu21Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC; IP.
Assay KitsSEA739HuELISA Kit for Cyclin Dependent Kinase 5 (CDK5)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteinsn/aRecombinant Cyclin Dependent Kinase 5 (CDK5)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)Polyclonal Antibody Customized Service Offer
Assay KitsSEA739MuELISA Kit for Cyclin Dependent Kinase 5 (CDK5)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

ProteinsRPA739Ra01Recombinant Cyclin Dependent Kinase 5 (CDK5)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA739Ra01Polyclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC; IP.
MAA739Ra21Monoclonal Antibody to Cyclin Dependent Kinase 5 (CDK5)WB; IHC; ICC; IP.
Assay KitsSEA739RaELISA Kit for Cyclin Dependent Kinase 5 (CDK5)Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A family of human cdc2-related protein kinases."EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling."Mol. Biol. Rep. 37:2415-2421(2010) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5."Eur. J. Biochem. 243:527-536(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth."J. Neurosci. 18:9858-9869(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 96:11156-11160(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35."Brain Res. Mol. Brain Res. 106:50-56(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein."Biochem. Biophys. Res. Commun. 310:398-404(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis."Neuron 38:33-46(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation."J. Neurochem. 94:1535-1545(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation."J. Biol. Chem. 282:1687-1694(2007) [PubMed] [Europe PMC] [Abstract]
  13. "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."J. Cell. Biochem. 100:738-749(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death."J. Cell Sci. 120:2259-2271(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin."J. Cell Sci. 120:4355-4366(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons."J. Neurosci. 27:7318-7328(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35."J. Neurosci. Res. 85:3071-3078(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes."J. Neurochem. 106:1325-1336(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity."Neuron 60:803-817(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis."J. Biol. Chem. 285:35932-35943(2010) [PubMed] [Europe PMC] [Abstract]
  26. "CDK5 phosphorylates eNOS at Ser-113 and regulates NO production."J. Cell. Biochem. 110:112-117(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25."Bioorg. Med. Chem. 19:359-373(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)."Cell. Mol. Life Sci. 68:3425-3436(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils."J. Cell. Physiol. 227:739-750(2012) [PubMed] [Europe PMC] [Abstract]
  31. "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity."J. Neurochem. 118:902-914(2011) [PubMed] [Europe PMC] [Abstract]
  32. "High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization."Mol. Biol. Cell 22:703-714(2011) [PubMed] [Europe PMC] [Abstract]
  33. "Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease."Nat. Cell Biol. 13:568-579(2011) [PubMed] [Europe PMC] [Abstract]
  34. "Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control."Proc. Natl. Acad. Sci. U.S.A. 108:1415-1420(2011) [PubMed] [Europe PMC] [Abstract]
  35. "A decade of CDK5."Nat. Rev. Mol. Cell Biol. 2:749-759(2001) [PubMed] [Europe PMC] [Abstract]
  36. "Cell cycle, CDKs and cancer: a changing paradigm."Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
  37. "Making a neuron: Cdk5 in embryonic and adult neurogenesis."Trends Neurosci. 32:575-582(2009) [PubMed] [Europe PMC] [Abstract]
  38. "Cdk5, the multifunctional surveyor."Cell Cycle 9:284-311(2010) [PubMed] [Europe PMC] [Abstract]
  39. "Regulation and role of cyclin-dependent kinase activity in neuronal survival and death."J. Neurochem. 115:1309-1321(2010) [PubMed] [Europe PMC] [Abstract]
  40. "Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons."Cell Cycle 10:1208-1214(2011) [PubMed] [Europe PMC] [Abstract]
  41. "Cdk5: Mediator of neuronal development, death and the response to DNA damage."Mech. Ageing Dev. 132:389-394(2011) [PubMed] [Europe PMC] [Abstract]
  42. "Cdk5: multitasking between physiological and pathological conditions."Prog. Neurobiol. 94:49-63(2011) [PubMed] [Europe PMC] [Abstract]
  43. "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
  44. "Structure and regulation of the CDK5-p25(nck5a) complex."Mol. Cell 8:657-669(2001) [PubMed] [Europe PMC] [Abstract]
  45. "Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation."Chem. Biol. 12:811-823(2005) [PubMed] [Europe PMC] [Abstract]
  46. "Mechanism of CDK5/p25 binding by CDK inhibitors."J. Med. Chem. 48:671-679(2005) [PubMed] [Europe PMC] [Abstract]
  47. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]