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Ficolin 1 (FCN1)

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FCNM; Collagen/fibrinogen domain-containing protein 1; Ficolin-alpha; Ficolin-A; M-ficolin

Ficolin 1 (FCN1)
CCC A786
HGNC 3623
MGI 1341158
PubMed 19741154
RGD 621221
UniProt O00602
Wiki FCN1

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct.

Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA786Hu01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA786Hu02 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA786Hu01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
MAA786Hu22 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
Assay Kits SEA786Hu ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA786Mu01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA786Mu02 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA786Mu01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
PAA786Mu02 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
Assay Kits SEA786Mu ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA786Ra01 Recombinant Ficolin 1 (FCN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA786Ra01 Polyclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
MAA786Ra21 Monoclonal Antibody to Ficolin 1 (FCN1) WB; IHC; ICC; IP.
Assay Kits SEA786Ra ELISA Kit for Ficolin 1 (FCN1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA786Ra CLIA Kit for Ficolin 1 (FCN1) Chemiluminescent immunoassay for Antigen Detection.
  1. "Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9."Biochem. J. 313:473-478(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1."J. Biochem. 120:745-751(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."J. Immunol. 185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain."J. Leukoc. Biol. 88:145-158(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain."J. Biol. Chem. 282:3889-3895(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch."J. Biol. Chem. 282:35814-35820(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin."J. Biol. Chem. 285:6612-6622(2010) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]