Death receptor 5 (DR5)

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CD262; TNFRSF10B; KILLER; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; Tumor Necrosis Factor Receptor Superfamily, Member 10B

Death receptor 5 (DR5)

TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells. Using a combination of PCR and library screening, the authors isolated cDNAs corresponding to the TRAILR2 coding region. The predicted 440-amino acid protein contains a putative signal peptide, 2 cysteine-rich pseudorepeats characteristic of TNF receptor (TNFR) family members, a transmembrane domain, and an intracellular death domain. The death domain of TRAILR2 shares 30% identity with that of TNFR1. Overall, the TRAIL receptors TRAILR2 and TRAILR1 (DR4) are 58% identical. Northern blot analysis indicated that TRAILR2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA818Hu01 Recombinant Death receptor 5 (DR5) Positive Control; Immunogen; SDS-PAGE; WB.
APA818Hu01 Active Death receptor 5 (DR5) Cell culture; Activity Assays.
Antibodies PAA818Hu01 Polyclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC; IP.
Assay Kits SEA818Hu ELISA Kit for Death receptor 5 (DR5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA818Mu01 Recombinant Death receptor 5 (DR5) Positive Control; Immunogen; SDS-PAGE; WB.
RPA818Mu02 Recombinant Death receptor 5 (DR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA818Mu01 Polyclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC; IP.
PAA818Mu02 Polyclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC; IP.
LAA818Mu71 Biotin-Linked Polyclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Death receptor 5 (DR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Death receptor 5 (DR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA818Ra01 Recombinant Death receptor 5 (DR5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA818Ra01 Polyclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC; IP.
MAA818Ra21 Monoclonal Antibody to Death receptor 5 (DR5) WB; IHC; ICC; IP.
Assay Kits SEA818Ra ELISA Kit for Death receptor 5 (DR5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL."Curr. Biol. 7:693-696(1997) [PubMed] [Europe PMC] [Abstract]
  2. "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL."EMBO J. 16:5386-5397(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of two receptors for TRAIL."FEBS Lett. 416:329-334(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."Immunity 7:821-830(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."J. Biol. Chem. 272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]
  6. "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene."Nat. Genet. 17:141-143(1997) [PubMed] [Europe PMC] [Abstract]
  7. "An antagonist decoy receptor and a death domain-containing receptor for TRAIL."Science 277:815-818(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors."Science 277:818-821(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas."Cancer Lett. 133:197-204(1998) [PubMed] [Europe PMC] [Abstract]
  10. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  12. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  14. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  15. "CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."J. Biol. Chem. 279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."Cell Host Microbe 13:324-335(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."Mol. Cell 4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."Nat. Struct. Biol. 6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions."PLoS Pathog. 9:E1003224-E1003224(2013) [PubMed] [Europe PMC] [Abstract]