Nitric Oxide Synthase 2, Inducible (NOS2)

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NOS2A; INOS; HEP-NOS; I-NOS; Hepatocytes Oxide Synthase; Peptidyl-cysteine S-nitrosylase NOS2

Nitric Oxide Synthase 2, Inducible (NOS2)

Nitric oxide synthase 2A (inducible, hepatocytes)is an enzyme encoded by the NOS2 gene. is produced by a group of enzymes called nitric oxide synthases (NOS). These enzymes catalyze the production of NO and L-citrulline from L-arginine, O2, and NADPH-derived electrons. Mammalian systems contain three well-characterized isoforms of the enzyme: neuronal NOS (nNOS, also called NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). The names reflect characteristics of the activity or the original tissues in which the enzymes were first described, but it is now known that each of these isoforms is expressed in a variety of tissues and cell types . The three main isoforms share structural similarities and have nearly identical catalytic mechanisms.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA837Hu01Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
RPA837Hu02Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA837Hu01Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
MAA837Hu22Monoclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
PAA837Hu02Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
LAA837Hu71Biotin-Linked Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA837HuELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA837Mu01Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
RPA837Mu02Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
RPA837Mu03Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA837Mu01Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
PAA837Mu02Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
PAA837Mu03Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
LAA837Mu71Biotin-Linked Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)IHC;WB;ELISA
Assay KitsSEA837MuELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA837Ra01Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
RPA837Ra02Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA837Ra01Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
MAA837Ra21Monoclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
PAA837Ra02Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA837RaELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA837Rb01Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA837Rb51Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
MAA837Rb21Monoclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA837RbELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPA837Ca01Recombinant Nitric Oxide Synthase 2, Inducible (NOS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAA837Ca01Polyclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
MAA837Ca21Monoclonal Antibody to Nitric Oxide Synthase 2, Inducible (NOS2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEA837CaELISA Kit for Nitric Oxide Synthase 2, Inducible (NOS2)Enzyme-linked immunosorbent assay for Antigen Detection
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  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  12. "Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B, and NOS2C) colocalize to human chromosome 17."Genomics 27:526-530(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Inducible nitric oxide synthase in the liver: regulation and function."Biochemistry (Mosc.) 63:766-781(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output."J. Biol. Chem. 277:33132-33138(2002) [PubMed] [Europe PMC] [Abstract]
  15. "A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children."Lancet 360:1468-1475(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Target-selective protein S-nitrosylation by sequence motif recognition."Cell 159:623-634(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Zinc regulates iNOS-derived nitric oxide formation in endothelial cells."Redox Biol. 2:945-954(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase."J. Biol. Chem. 274:21276-21284(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation."Nat. Struct. Biol. 6:233-242(1999) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease."Clin. Transl. Gastroenterol. 5:E46-E46(2014) [PubMed] [Europe PMC] [Abstract]