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Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL)

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CD254; TNFSF11; ODF; OPGL; TRANCE; HRANKL2; SOdf; Tumor Necrosis Factor(ligand)superfamily Member 11; TNF-related activation-induced cytokine

Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL)
CCC A855
HGNC 11926
MGI 1100089
PubMed 19191757
RGD 620784
UniProt O14788
Wiki RANKL

RANKL a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA855Hu01 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA855Hu02 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA855Hu01 Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Hu22 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Hu21 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
LAA855Hu72 Biotin-Linked Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC.
Assay Kits SEA855Hu ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA855Hu CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA855Mu01 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
RPA855Mu02 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
EPA855Mu61 Eukaryotic Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
APA855Mu61 Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Cell culture; Activity Assays.
APA855Mu01 Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Cell culture; Activity Assays.
Antibodies PAA855Mu01 Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
PAA855Mu02 Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
Assay Kits SEA855Mu ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA855Ra01 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
APA855Ra61 Active Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Cell culture; Activity Assays.
Antibodies PAA855Ra01 Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Ra21 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Ra24 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Ra26 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
LAA855Ra76 Biotin-Linked Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC.
MAA855Ra22 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
MAA855Ra23 Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
Assay Kits SEA855Ra ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA855Ra CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Polyclonal Antibody Customized Service Offer
Assay Kits SEA855Ca ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA855Ga01 Recombinant Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA855Ga01 Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B Ligand (RANkL) ELISA Kit Customized Service Offer
  1. "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."Nature 390:175-179(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation." Cell 93:165-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation."Biochem. Biophys. Res. Commun. 269:532-536(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."J. Biol. Chem. 272:25190-25194(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."J. Immunol. 189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL." Nat. Genet. 39:960-962(2007) [PubMed] [Europe PMC] [Abstract]