Mucin 4 (MUC4)

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ASGP; Mucin 4 Cell Surface Associated; Mucin 4,Tracheobronchial; Testis mucin; Ascites sialoglycoprotein; Pancreatic adenocarcinoma mucin

Mucin 4 (MUC4)

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. MUC4  gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats, although only two repeats are included in these sequences.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB034Hu01Recombinant Mucin 4 (MUC4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB034Hu01Polyclonal Antibody to Mucin 4 (MUC4)WB, ICC, IHC-P, IHC-F, ELISA
MAB034Hu22Monoclonal Antibody to Mucin 4 (MUC4)WB, ICC, IHC-P, IHC-F, ELISA
LAB034Hu71Biotin-Linked Polyclonal Antibody to Mucin 4 (MUC4)IHC;WB;ELISA
Assay KitsSEB034HuELISA Kit for Mucin 4 (MUC4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB034Mu01Recombinant Mucin 4 (MUC4)SDS-PAGE; WB; ELISA; IP.
RPB034Mu02Recombinant Mucin 4 (MUC4)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB034Mu01Polyclonal Antibody to Mucin 4 (MUC4)WB, ICC, IHC-P, IHC-F, ELISA
PAB034Mu02Polyclonal Antibody to Mucin 4 (MUC4)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB034MuELISA Kit for Mucin 4 (MUC4)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Mucin 4 (MUC4)Recombinant Protein Customized Service Offer
AntibodiesPAB034Ra01Polyclonal Antibody to Mucin 4 (MUC4)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Mucin 4 (MUC4)CLIA Kit Customized Service Offer
n/aELISA Kit for Mucin 4 (MUC4)ELISA Kit Customized Service Offer
  1. "Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins."Eur. J. Biochem. 267:4536-4544(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human MUC4 mucin cDNA and its variants in pancreatic carcinoma."J. Biochem. 128:233-243(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4."Eur. J. Biochem. 269:3150-3159(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin."Biochem. J. 338:325-333(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization of MUC4 mucin gene: towards the characterization of splice variants."Eur. J. Biochem. 269:3637-3644(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs."Biochem. Biophys. Res. Commun. 175:414-422(1991) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive."Prog. Nucleic Acid Res. Mol. Biol. 71:149-185(2002) [PubMed] [Europe PMC] [Abstract]
  9. "MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas."J. Clin. Pathol. 58:845-852(2005) [PubMed] [Europe PMC] [Abstract]
  10. "MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC)."Pathol. Res. Pract. 202:577-583(2006) [PubMed] [Europe PMC] [Abstract]
  11. "MUC4 expression and localization in gastrointestinal tract and skin of human embryos."Tissue Cell 38:271-275(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]