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Dopachrome Tautomerase (DCT)

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TYRP2; TRP-2; DT; Dopachrome Delta-Isomerase; Tyrosine-Related Protein 2; L-dopachrome Delta-isomerase

Dopachrome Tautomerase (DCT)
CCC B066
HGNC 2709
MGI 102563
PubMed 11180971
RGD 1564975
UniProt P40126
Wiki DCT

Dopachrome tautomerase , also known as DCT, is an enzyme that isomerizes the melanogenic intermediate 3,4-dihydroxyphenylalanine-chrome (DOPAchrome) to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) in the biosynthesis of melanin. Its expression is regulated by the Microphthalmia-associated transcription factor.

human TYRP2 protein has 83% identity and 90% similarity to the mouse sequence and has all the structural characteristics of the tyrosinase protein family, including a signal peptide, 15 conserved cysteine residues, 2 copper-binding domains, and a C-terminal membrane-spanning region. Northern blot analysis showed that TYRP2 is expressed at high levels in human melanoma cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB066Hu01 Recombinant Dopachrome Tautomerase (DCT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB066Hu01 Polyclonal Antibody to Dopachrome Tautomerase (DCT) WB; IHC; ICC; IP.
MAB066Hu22 Monoclonal Antibody to Dopachrome Tautomerase (DCT) WB; IHC; ICC; IP.
Assay Kits SEB066Hu ELISA Kit for Dopachrome Tautomerase (DCT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopachrome Tautomerase (DCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopachrome Tautomerase (DCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopachrome Tautomerase (DCT) Polyclonal Antibody Customized Service Offer
Assay Kits SEB066Mu ELISA Kit for Dopachrome Tautomerase (DCT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopachrome Tautomerase (DCT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopachrome Tautomerase (DCT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopachrome Tautomerase (DCT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopachrome Tautomerase (DCT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopachrome Tautomerase (DCT) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2."Biochim. Biophys. Acta 1217:317-321(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA."Gene 143:295-298(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells."Eur. J. Biochem. 219:127-134(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy."J. Immunol. 168:951-956(2002) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family."Genomics 29:24-34(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression."J. Biol. Chem. 269:27080-27087(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."J. Proteome Res. 2:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]