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Interleukin 12 Receptor Beta 2 (IL12Rb2)

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IL12R-B2; IL12-RB2; RP11-102M16.1

Interleukin 12 Receptor Beta 2 (IL12Rb2)
CCC B073
HGNC 5972
MGI 1270861
PubMed 18353079
RGD 620026
UniProt Q99665
Wiki IL12RB2
Interleukin 12 receptor, beta 2 subunit is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.
The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB073Hu01 Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB073Hu02 Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB073Hu01 Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC; IP.
MAB073Hu22 Monoclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC; IP.
LAB073Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC.
PAB073Hu02 Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC; IP.
Assay Kits SEB073Hu ELISA Kit for Interleukin 12 Receptor Beta 2 (IL12Rb2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB073Mu01 Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) Positive Control; Immunogen; SDS-PAGE; WB.
RPB073Mu02 Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB073Mu01 Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC; IP.
PAB073Mu02 Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 12 Receptor Beta 2 (IL12Rb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 12 Receptor Beta 2 (IL12Rb2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 12 Receptor Beta 2 (IL12Rb2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 12 Receptor Beta 2 (IL12Rb2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 12 Receptor Beta 2 (IL12Rb2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 12 Receptor Beta 2 (IL12Rb2) ELISA Kit Customized Service Offer
  1. "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human interleukin-12 receptor beta2-chain gene."Immunogenetics 51:30-36(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Direct interaction of STAT4 with the IL-12 receptor."Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus."Biochem. Biophys. Res. Commun. 257:400-404(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling."J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Selective expression of an interleukin-12 receptor component by human T helper 1 cells."J. Exp. Med. 185:825-831(1997) [PubMed] [Europe PMC] [Abstract]
  9. "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit."Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations of the IL-12 receptor beta2 chain gene in atopic subjects."Biochem. Biophys. Res. Commun. 266:551-555(1999) [PubMed] [Europe PMC] [Abstract]