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Cytochrome P450 3A1 (CYP3A1)

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CYPIIIA1; Cytochrome P450-PCN1

Cytochrome P450 3A1 (CYP3A1)
CCC B150
PubMed 21718287
RGD 628626
UniProt P04800
Thymoquinone protected against renal I/R-induced damage through an antioxidant mechanism as well as the decrease of CYP3A1 and SSAT gene expression.
Thymoquinone treatment caused the reversal of I/R-induced changes in MDA as well as GST and SOD activity. Moreover, I/R caused a significant rise in creatinine and alanine aminotransferase serum levels. CYP3A1 mRNA expression was induced significantly by I/R in both liver and kidney tissues compared with sham group. Thymoquinone reduced significantly this increase. I/R caused induction of mRNA expression of spermidine/spermine N-1-acetyl-transferase (SSAT), a catabolic enzyme that participates in polyamine metabolism, in liver and kidney tissues. Thymoquinone reduced SSAT mRNA expression significantly in liver and markedly in kidney.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 3A1 (CYP3A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 3A1 (CYP3A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 3A1 (CYP3A1) Polyclonal Antibody Customized Service Offer
Assay Kits SEB150Ra ELISA Kit for Cytochrome P450 3A1 (CYP3A1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family."J. Biol. Chem. 260:7435-7441(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a novel CYP3A1 allelic variant: analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone."Arch. Biochem. Biophys. 293:147-152(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Purification and characterization of four catalytically active testosterone 6 beta-hydroxylase P-450s from rat liver microsomes: comparison of a novel form with three structurally and functionally related forms."J. Biochem. 107:718-725(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats."Arch. Biochem. Biophys. 301:345-354(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes."Proc. Natl. Acad. Sci. U.S.A. 89:2145-2149(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: changes during development."Arch. Biochem. Biophys. 298:715-725(1992) [PubMed] [Europe PMC] [Abstract]