Tetraspanin 27 (TSPAN27)

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CD82; R2; IA4; 4F9; C33; GR15; KAI1; SAR2; ST6; Kangai 1; Suppression Of Tumorigenicity 6,prostate); R2 Leukocyte Antigen; Antigen Detected By Monoclonal And Antibody IA4

Tetraspanin 27 (TSPAN27)

CD82 (Cluster of Differentiation 82) is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter.

Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Tetraspanin 27 (TSPAN27)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Tetraspanin 27 (TSPAN27)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Tetraspanin 27 (TSPAN27)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Tetraspanin 27 (TSPAN27)CLIA Kit Customized Service Offer
n/aELISA Kit for Tetraspanin 27 (TSPAN27)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Tetraspanin 27 (TSPAN27)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Tetraspanin 27 (TSPAN27)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Tetraspanin 27 (TSPAN27)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Tetraspanin 27 (TSPAN27)CLIA Kit Customized Service Offer
n/aELISA Kit for Tetraspanin 27 (TSPAN27)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Tetraspanin 27 (TSPAN27)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Tetraspanin 27 (TSPAN27)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Tetraspanin 27 (TSPAN27)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Tetraspanin 27 (TSPAN27)CLIA Kit Customized Service Offer
n/aELISA Kit for Tetraspanin 27 (TSPAN27)ELISA Kit Customized Service Offer
  1. "A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23."Eur. J. Immunol. 21:377-383(1991) [PubMed] [Europe PMC] [Abstract]
  2. "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63."J. Immunol. 149:2879-2886(1992) [PubMed] [Europe PMC] [Abstract]
  3. "KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2."Science 268:884-886(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of the human KAI1 metastasis-suppressor gene."Genomics 41:25-32(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells."Cancer Res. 63:2665-2674(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]