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Cluster Of Differentiation 4 (CD4)

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CD4mut; p55; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3

Cluster Of Differentiation 4 (CD4)
CCC B167
HGNC 1678
MGI 88335
PubMed 15234856
RGD 2306
UniProt P01730
Wiki CD4

CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984.In humans, the CD4 protein is encoded by the CD4 gene. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR by recruiting an enzyme, known as the tyrosine kinase lck, which is essential for activating many molecules involved in the signaling cascade of an activated T cell.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB167Hu01 Recombinant Cluster Of Differentiation 4 (CD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB167Hu01 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
MAB167Hu22 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
LAB167Hu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC.
MAB167Hu21 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
MAB167Hu23 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
MAB167Hu24 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC
MAB167Hu25 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
Assay Kits SEB167Hu ELISA Kit for Cluster Of Differentiation 4 (CD4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB167Mu01 Recombinant Cluster Of Differentiation 4 (CD4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB167Mu02 Recombinant Cluster Of Differentiation 4 (CD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB167Mu01 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
LAB167Mu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC.
PAB167Mu02 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
MAB167Mu21 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
MAB167Mu31 Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
Assay Kits SEB167Mu ELISA Kit for Cluster Of Differentiation 4 (CD4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins CPB167Ra21 OVA Conjugated Cluster Of Differentiation 4 (CD4) Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 4 (CD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 4 (CD4) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB167Rb01 Recombinant Cluster Of Differentiation 4 (CD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB167Rb51 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
PAB167Rb01 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 4 (CD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 4 (CD4) ELISA Kit Customized Service Offer

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB167Si01 Recombinant Cluster Of Differentiation 4 (CD4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB167Si01 Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC; IP.
LAB167Si71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 4 (CD4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 4 (CD4) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 4 (CD4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 4 (CD4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 4 (CD4) Polyclonal Antibody Customized Service Offer
Assay Kits SEB167Ga ELISA Kit for Cluster Of Differentiation 4 (CD4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family."Cell 42:93-104(1985) [PubMed] [Europe PMC] [Abstract]
  2. "Corrected CD4 sequence."Cell 55:541-541(1988) [PubMed] [Europe PMC] [Abstract]
  3. "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13."Genome Res. 6:314-326(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Humans with OKT4-epitope deficiency have a single nucleotide base change in the CD4 gene, resulting in substitution of TRP240 for ARG240."Hum. Immunol. 30:99-104(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus."Eur. J. Immunol. 22:2973-2981(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry."J. Biol. Chem. 264:21286-21295(1989) [PubMed] [Europe PMC] [Abstract]
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A single amino acid substitution in a common African allele of the CD4 molecule ablates binding of the monoclonal antibody, OKT4."Mol. Immunol. 28:1171-1181(1991) [PubMed] [Europe PMC] [Abstract]
  12. "CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor."J. Virol. 64:5585-5593(1990) [PubMed] [Europe PMC] [Abstract]
  13. "Carbohydrate structures of recombinant soluble human CD4 expressed in Chinese hamster ovary cells."Biochemistry 30:2395-2406(1991) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of palmitoylation sites on CD4, the human immunodeficiency virus receptor."J. Biol. Chem. 267:13593-13597(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain."Cell 76:853-864(1994) [PubMed] [Europe PMC] [Abstract]
  16. "CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus."Proc. Natl. Acad. Sci. U.S.A. 91:3872-3876(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Cloning of ACP33 as a novel intracellular ligand of CD4."J. Biol. Chem. 276:9123-9132(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling."J. Immunol. 170:913-921(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Protein minimization of the gp120 binding region of human CD4."Biochemistry 44:16192-16202(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains."Nature 348:411-418(1990) [PubMed] [Europe PMC] [Abstract]
  22. "Crystal structure of an HIV-binding recombinant fragment of human CD4."Nature 348:419-426(1990) [PubMed] [Europe PMC] [Abstract]
  23. "Dimeric association and segmental variability in the structure of human CD4."Nature 387:527-530(1997) [PubMed] [Europe PMC] [Abstract]
  24. "Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody."Nature 393:648-659(1998) [PubMed] [Europe PMC] [Abstract]
  25. "Structural basis for the interaction between focal adhesion kinase and CD4."J. Mol. Biol. 375:1320-1328(2008) [PubMed] [Europe PMC] [Abstract]