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Asialoglycoprotein Receptor 1 (ASGR1)

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CLEC4H1; HL-1; ASGPR 1; Asialoglyco protein Receptor; C-type lectin domain family 4 member H1; Hepatic lectin H1

Asialoglycoprotein Receptor 1 (ASGR1)
CCC B189
HGNC 742
MGI 88081
PubMed 21848542
RGD 2160
UniProt P07306
Wiki ASGR

The asialoglycoprotein receptor binds to desialylated (galactosyl-terminal) glycoproteins. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociate.

The ASGR1 gene encodes a glycoprotein that forms the asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. Partially deglycosylated plasma glycoproteins are efficiently and specifically removed from the circulation via this receptor-ligand complex. Many functional studies describing the kinetics of ligand-binding, internalization, and recycling of such receptors have been performed on the human hepatoma cell line HepG2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB189Hu01 Recombinant Asialoglycoprotein Receptor 1 (ASGR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB189Hu01 Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) WB; IHC; ICC; IP.
MAB189Hu22 Monoclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) WB; IHC; ICC; IP.
Assay Kits SEB189Hu ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB189Mu01 Recombinant Asialoglycoprotein Receptor 1 (ASGR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB189Mu01 Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Asialoglycoprotein Receptor 1 (ASGR1) Recombinant Protein Customized Service Offer
Antibodies PAB189Ra01 Polyclonal Antibody to Asialoglycoprotein Receptor 1 (ASGR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Asialoglycoprotein Receptor 1 (ASGR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Asialoglycoprotein Receptor 1 (ASGR1) ELISA Kit Customized Service Offer
  1. "Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion."J. Biol. Chem. 260:1979-1982(1985) [PubMed] [Europe PMC] [Abstract]
  2. "An internal signal sequence: the asialoglycoprotein receptor membrane anchor."Cell 44:177-185(1986) [PubMed] [Europe PMC] [Abstract]
  3. "A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes."PLoS ONE 5:E12934-E12934(2010) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits."J. Biol. Chem. 271:32454-32460(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1."Genomics 77:58-64(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor."J. Mol. Biol. 300:857-865(2000) [PubMed] [Europe PMC] [Abstract]