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Alkaline Phosphatase, Placental (ALPP)

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PLAP1; ALP; ALPG; ALPPL; GCAP; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1

Alkaline Phosphatase, Placental (ALPP)
CCC B219
HGNC 439
MGI 108009
PubMed 2148879
UniProt P05187
Wiki ALPP

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).

Alkaline phosphatase, placental is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB219Hu01 Recombinant Alkaline Phosphatase, Placental (ALPP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB219Hu02 Recombinant Alkaline Phosphatase, Placental (ALPP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB219Hu01 Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) WB; IHC; ICC; IP.
MAB219Hu22 Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) WB; IHC; ICC; IP.
Assay Kits SEB219Hu ELISA Kit for Alkaline Phosphatase, Placental (ALPP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alkaline Phosphatase, Placental (ALPP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alkaline Phosphatase, Placental (ALPP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Alkaline Phosphatase, Placental (ALPP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkaline Phosphatase, Placental (ALPP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB219Ra01 Recombinant Alkaline Phosphatase, Placental (ALPP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB219Ra01 Polyclonal Antibody to Alkaline Phosphatase, Placental (ALPP) WB
Assay Kits n/a CLIA Kit for Alkaline Phosphatase, Placental (ALPP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkaline Phosphatase, Placental (ALPP) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution."J. Biol. Chem. 263:12020-12027(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and sequence analysis of human placental alkaline phosphatase."J. Biol. Chem. 261:3112-3115(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids."Proc. Natl. Acad. Sci. U.S.A. 83:5597-5601(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA."Proc. Natl. Acad. Sci. U.S.A. 82:8715-8719(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and partial sequencing of human placental alkaline phosphatase."Biochem. Biophys. Res. Commun. 116:1076-1083(1983) [PubMed] [Europe PMC] [Abstract]
  8. "Expression of different-sized placental alkaline phosphatase mRNAs in placenta and choriocarcinoma cells."Proc. Natl. Acad. Sci. U.S.A. 83:3781-3785(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme."Proc. Natl. Acad. Sci. U.S.A. 85:1398-1402(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase."Proc. Natl. Acad. Sci. U.S.A. 87:157-161(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein."J. Cell Biol. 116:799-807(1992) [PubMed] [Europe PMC] [Abstract]
  12. "Function assignment to conserved residues in mammalian alkaline phosphatases."J. Biol. Chem. 277:22992-22999(2002) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity."J. Biol. Chem. 276:9158-9165(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Structural studies of human placental alkaline phosphatase in complex with functional ligands."J. Mol. Biol. 350:441-451(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones."Protein Sci. 15:1691-1700(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site."Acta Crystallogr. F 66:866-870(2010) [PubMed] [Europe PMC] [Abstract]