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Cytokeratin 19 (CK19)

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K19; KRT19; K1CS; Keratin 19; 40-kDa Keratin Intermediate Filament; Keratin, type I cytoskeletal 19

Cytokeratin 19 (CK19)
CCC B239
HGNC 6436
MGI 96693
PubMed 8743949
RGD 619936
UniProt P08727
Wiki Keratin_19

  • Keratin, type I cytoskeletal 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains.

    Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.Keratin 19 is a type I cytokeratin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB239Hu01 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Hu02 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB239Hu61 Eukaryotic Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Hu07 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
APB239Hu61 Active Cytokeratin 19 (CK19) Cell culture; Activity Assays.
RPB239Hu03 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Hu04 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Hu05 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Hu06 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
EPB239Hu62 Eukaryotic Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB239Hu01 Polyclonal Antibody to Cytokeratin 19 (CK19) WB,IHC
MAB239Hu22 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
LAB239Hu71 Biotin-Linked Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC.
MAB239Hu21 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
PAB239Hu02 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC
MAB239Hu23 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
MAB239Hu24 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
PAB239Hu03 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
MAB239Hu25 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
MAB239Hu27 Monoclonal Antibody to Cytokeratin 19 (CK19) WB
MAB239Hu29 Monoclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
PAB239Hu06 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
PAB239Hu07 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
Assay Kits SEB239Hu ELISA Kit for Cytokeratin 19 (CK19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB239Mu01 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
RPB239Mu02 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB239Mu01 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
LAB239Mu71 Biotin-Linked Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC.
LAB239Mu81 FITC-Linked Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IF.
PAB239Mu02 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
Assay Kits SEB239Mu ELISA Kit for Cytokeratin 19 (CK19) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB239Ra01 Recombinant Cytokeratin 19 (CK19) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB239Ra01 Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC; IP.
LAB239Ra71 Biotin-Linked Polyclonal Antibody to Cytokeratin 19 (CK19) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Cytokeratin 19 (CK19) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytokeratin 19 (CK19) ELISA Kit Customized Service Offer
  1. "Sequence of cDNA coding for human keratin 19."Nucleic Acids Res. 15:10058-10058(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin."Proc. Natl. Acad. Sci. U.S.A. 85:1114-1118(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins."J. Invest. Dermatol. 92:707-716(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization and amplification of the human keratin 15 and 19 genes."Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line."J. Hepatol. 35:504-511(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
  11. "Diversity of keratin 19 gene expressed in lymph nodes of breast cancer patients -- strategy to clear the discrepancy between histological findings and RT-PCR results in the detection of micrometastasis."Seibutsu Butsuri Kagaku 44:201-204(2000)
  12. "Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization."J. Biol. Chem. 274:12861-12866(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus."J. Biol. Chem. 275:14910-14915(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19."Mol. Biol. Cell 16:4280-4293(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of in vivo keratin 19 phosphorylation on tyrosine-391."PLoS ONE 5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]