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Chymotrypsin C (CTRC)

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ELA4; CTRC; Elastase 4 ; Caldecrin

Chymotrypsin C (CTRC)
CCC B310
HGNC 2523
MGI 1923951
PubMed 9651152
RGD 1308379
UniProt Q99895
Wiki CLCR

  • Elastase 4 is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. These human caldecrin isoforms, like the rat preproenzyme, are composed of a signal peptide of 16 amino acids, a propeptide of 13 amino acids, and a mature form of 239 amino acids. Both recombinant caldecrins, produced in a baculovirus expression system, showed the same chymotrypsin-type protease activity and hypocalcemic activity. The hypocalcemic activity of both caldecrin isoforms remained intact even after treatment with phenylmethylsulfonyl fluoride (PMSF) to abolish their protease activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB310Hu01 Recombinant Chymotrypsin C (CTRC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB310Hu01 Polyclonal Antibody to Chymotrypsin C (CTRC) WB; IHC; ICC; IP.
MAB310Hu22 Monoclonal Antibody to Chymotrypsin C (CTRC) WB; IHC; ICC; IP.
Assay Kits SEB310Hu ELISA Kit for Chymotrypsin C (CTRC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB310Mu01 Recombinant Chymotrypsin C (CTRC) Positive Control; Immunogen; SDS-PAGE; WB.
RPB310Mu02 Recombinant Chymotrypsin C (CTRC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB310Mu01 Polyclonal Antibody to Chymotrypsin C (CTRC) WB; IHC; ICC; IP.
PAB310Mu02 Polyclonal Antibody to Chymotrypsin C (CTRC) WB; IHC; ICC; IP.
Assay Kits SEB310Mu ELISA Kit for Chymotrypsin C (CTRC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB310Ra01 Recombinant Chymotrypsin C (CTRC) Positive Control; Immunogen; SDS-PAGE; WB.
APB310Ra01 Active Chymotrypsin C (CTRC) Cell culture; Activity Assays.
Antibodies PAB310Ra01 Polyclonal Antibody to Chymotrypsin C (CTRC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Chymotrypsin C (CTRC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chymotrypsin C (CTRC) ELISA Kit Customized Service Offer
  1. "Molecular cloning and expression of human caldecrin."FEBS Lett. 386:26-28(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation."J. Biol. Chem. 288:9848-9859(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis."Hum. Genet. 123:83-91(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis." Nat. Genet. 40:78-82(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan."Pancreatology 9:287-292(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis."Gut 62:653-654(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants."Gut 62:1602-1606(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk."Gut 62:1616-1624(2013) [PubMed] [Europe PMC] [Abstract]