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Calcineurin (CaN)

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PPP3CA; PPP3-CA; CCN1; CNA1; CALN; CALNA1; PP2B; PP2-B; Protein Phosphatase 3(formerly 2B),Catalytic Subunit,Alpha Isoformprotein Phosphatase 2B; Calcineurin A Alpha

Calcineurin (CaN)
CCC B323
HGNC 9314
MGI 107164
PubMed 11015619
RGD 3382
UniProt Q08209
Wiki Calcineurin

Calcineurin is responsible for activating the transcription of interleukin 2 (IL-2), that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus (Elidel) and tacrolimus (FK506) - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. Calcineurin is linked to receptors for two brain chemicals, NMDA and dopamine. A MIT experiment with genetically altered mice who could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior and several other abnormalities characteristic of schizophrenia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB323Hu01 Recombinant Calcineurin (CaN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB323Hu01 Polyclonal Antibody to Calcineurin (CaN) WB; IHC; ICC; IP.
MAB323Hu22 Monoclonal Antibody to Calcineurin (CaN) WB; IHC; ICC; IP.
Assay Kits SEB323Hu ELISA Kit for Calcineurin (CaN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcineurin (CaN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcineurin (CaN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcineurin (CaN) Polyclonal Antibody Customized Service Offer
Assay Kits SEB323Mu ELISA Kit for Calcineurin (CaN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB323Ra01 Recombinant Calcineurin (CaN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB323Ra01 Polyclonal Antibody to Calcineurin (CaN) WB; IHC; ICC; IP.
MAB323Ra21 Monoclonal Antibody to Calcineurin (CaN) WB; IHC; ICC; IP.
Assay Kits SEB323Ra ELISA Kit for Calcineurin (CaN) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."J. Biol. Chem. 280:12683-12689(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria."Proc. Natl. Acad. Sci. U.S.A. 105:15803-15808(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
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  17. "Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction."J. Mol. Biol. 369:1296-1306(2007) [PubMed] [Europe PMC] [Abstract]