Pituitary Adenylate Cyclase Activating Peptide (PACAP)
[Edit]ADCYAP1; PRP-48; Pituitary Adenylate Cyclase Activating Peptide
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Pituitary adenylate cyclase-activating peptide, adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells.
Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone but also functions as a neurotransmitter and neuromodulator. In addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This gene is composed of five exons. Exons 1 and 2 encode the 5' UTR and signal peptide, respectively; exon 4 encodes an adenylate cyclase-activating polypeptide 1-related peptide; and exon 5 encodes the mature peptide and 3' UTR.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB347Hu01 | Recombinant Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPB347Hu11 | BSA Conjugated Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Immunogen; SDS-PAGE; WB. | |
| CPB347Hu12 | BSA Conjugated Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB347Hu01 | Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Peptide (PACAP) | WB,IHC |
| MAB347Hu22 | Monoclonal Antibody to Pituitary Adenylate Cyclase Activating Peptide (PACAP) | WB; IHC; ICC; IP. | |
| Assay Kits | CEB347Hu | ELISA Kit for Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB347Mu01 | Recombinant Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB347Mu02 | Recombinant Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB347Mu01 | Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Peptide (PACAP) | WB; IHC; ICC; IP. |
| PAB347Mu02 | Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Peptide (PACAP) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB347Mu | ELISA Kit for Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| CEB347Mu | ELISA Kit for Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB347Ra01 | Recombinant Pituitary Adenylate Cyclase Activating Peptide (PACAP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB347Ra01 | Polyclonal Antibody to Pituitary Adenylate Cyclase Activating Peptide (PACAP) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Pituitary Adenylate Cyclase Activating Peptide (PACAP) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Pituitary Adenylate Cyclase Activating Peptide (PACAP) | ELISA Kit Customized Service Offer |
- "Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide."DNA Cell Biol. 11:21-30(1992) [PubMed] [Europe PMC] [Abstract]
- "Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene."Biochim. Biophys. Acta 1129:199-206(1992) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs."Biochem. Biophys. Res. Commun. 166:81-89(1990) [PubMed] [Europe PMC] [Abstract]
- "Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells."Sci. Signal. 6:RA51-RA51(2013) [PubMed] [Europe PMC] [Abstract]
- "Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy."Biochemistry 32:5832-5841(1993) [PubMed] [Europe PMC] [Abstract]
- "Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution."Int. J. Pept. Protein Res. 40:456-464(1992) [PubMed] [Europe PMC] [Abstract]
- "Conformation of a peptide ligand bound to its G-protein coupled receptor."Nat. Struct. Biol. 8:161-165(2001) [PubMed] [Europe PMC] [Abstract]
- "Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS."Proc. Natl. Acad. Sci. U.S.A. 104:7875-7880(2007) [PubMed] [Europe PMC] [Abstract]
- "Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes."Hum. Mutat. 19:572-573(2002) [PubMed] [Europe PMC] [Abstract]