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Granulysin (GNLY)

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NKG5; LAG-2; TLA519; T-Lymphocyte Activation Gene 519

Granulysin (GNLY)
CCC B517
HGNC 4414
PubMed 14499265
UniProt P22749
Wiki GNLY

Granulysin is a protein present in cytotoxic granules of cytotoxic T cells and natural killer cells. Granulysin is a member of the saposin-like protein (SAPLIP) family and is released from cytotoxic T cells upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms.

Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.Granulysin is a cytolytic and proinflammatory molecule first identified by a screen for genes expressed   “late”(3-5 days) after activation of human peripheral blood mononuclear cells.Granulysin is present in cytolytic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granulysin is made as a 15 kD molecule, and a portion of it is cleaved at both the amino and carboxy termini into a 9 kD form.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB517Hu01 Recombinant Granulysin (GNLY) Positive Control; Immunogen; SDS-PAGE; WB.
EPB517Hu61 Eukaryotic Granulysin (GNLY) Positive Control; Immunogen; SDS-PAGE; WB.
APB517Hu61 Active Granulysin (GNLY) Cell culture; Activity Assays.
Antibodies PAB517Hu01 Polyclonal Antibody to Granulysin (GNLY) WB; IHC; ICC; IP.
MAB517Hu22 Monoclonal Antibody to Granulysin (GNLY) WB; IHC; ICC; IP.
Assay Kits SEB517Hu ELISA Kit for Granulysin (GNLY) Enzyme-linked immunosorbent assay for Antigen Detection.
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "An antimicrobial activity of cytolytic T cells mediated by granulysin."Science 282:121-125(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Biosynthesis of granulysin, a novel cytolytic molecule."Mol. Immunol. 36:413-422(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Granulysin crystal structure and a structure-derived lytic mechanism."J. Mol. Biol. 325:355-365(2003) [PubMed] [Europe PMC] [Abstract]