Pulmonary Activation Regulated Chemokine (PARC)

[Edit]

CCL18; AMAC1; SCYA18; DCCK1; MIP-4; CKb7; Alternative Macrophage Activation Associated CC Chemokine 1; Chemokine C-C-Motif Ligand 18; Macrophage inflammatory protein 4

Pulmonary Activation Regulated Chemokine (PARC)
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.
Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). CCL18 is approximately 60% identical in amino acid sequence to CCL3. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and nonactivated lymphocytes.The gene for human CCL18 contains three exons and is located on chromosome 17.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB522Hu01Recombinant Pulmonary Activation Regulated Chemokine (PARC)SDS-PAGE; WB; ELISA; IP.
APB522Hu01Active Pulmonary Activation Regulated Chemokine (PARC)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAB522Hu01Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)WB, ICC, IHC-P, IHC-F, ELISA
MAB522Hu22Monoclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)WB, ICC, IHC-P, IHC-F, ELISA
LAB522Hu71Biotin-Linked Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)IHC;WB;ELISA
LAB522Hu81FITC-Linked Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)IHC;ICC;IF;WB
Assay KitsSEB522HuELISA Kit for Pulmonary Activation Regulated Chemokine (PARC)Enzyme-linked immunosorbent assay for Antigen Detection
SCB522HuCLIA Kit for Pulmonary Activation Regulated Chemokine (PARC)Chemiluminescent immunoassay for Antigen Detection
  1. "Macrophage inflammatory protein-3 and -4."Patent number US5504003, 02-APR-1996
  2. "A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes."J. Immunol. 159:1140-1149(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern."J. Immunol. 160:1411-1418(1998) [PubMed] [Europe PMC] [Abstract]
  4. "A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells."Nature 387:713-717(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes."Genomics 55:353-357(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization and biological characterization of the novel human CC chemokine DC-CK-1/PARC/MIP-4/SCYA18."Genomics 56:296-302(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases."J. Leukoc. Biol. 61:545-550(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Selective induction of CCL18/PARC by staphylococcal enterotoxins in mononuclear cells and enhanced levels in septic and rheumatoid arthritis."Eur. J. Immunol. 31:3755-3762(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma."J. Biol. Chem. 277:24584-24593(2002) [PubMed] [Europe PMC] [Abstract]
  12. "The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity."Cytokine 64:463-470(2013) [PubMed] [Europe PMC] [Abstract]