Pulmonary Activation Regulated Chemokine (PARC)


CCL18; AMAC1; SCYA18; DCCK1; MIP-4; CKb7; Alternative Macrophage Activation Associated CC Chemokine 1; Chemokine C-C-Motif Ligand 18; Macrophage inflammatory protein 4

Pulmonary Activation Regulated Chemokine (PARC)
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines.
Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). CCL18 is approximately 60% identical in amino acid sequence to CCL3. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and nonactivated lymphocytes.The gene for human CCL18 contains three exons and is located on chromosome 17.

Organism species: Homo sapiens (Human)

ProteinsRPB522Hu01Recombinant Pulmonary Activation Regulated Chemokine (PARC)SDS-PAGE; WB; ELISA; IP.
APB522Hu01Active Pulmonary Activation Regulated Chemokine (PARC)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAB522Hu01Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)WB, ICC, IHC-P, IHC-F, ELISA
MAB522Hu22Monoclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)WB, ICC, IHC-P, IHC-F, ELISA
LAB522Hu71Biotin-Linked Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)IHC;WB;ELISA
LAB522Hu81FITC-Linked Polyclonal Antibody to Pulmonary Activation Regulated Chemokine (PARC)IHC;ICC;IF;WB
Assay KitsSEB522HuELISA Kit for Pulmonary Activation Regulated Chemokine (PARC)Enzyme-linked immunosorbent assay for Antigen Detection
SCB522HuCLIA Kit for Pulmonary Activation Regulated Chemokine (PARC)Chemiluminescent immunoassay for Antigen Detection
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  5. "Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes."Genomics 55:353-357(1999) [PubMed] [Europe PMC] [Abstract]
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  12. "The disulfide bond between cysteine 10 and cysteine 34 is required for CCL18 activity."Cytokine 64:463-470(2013) [PubMed] [Europe PMC] [Abstract]