Platelet Factor 4 Variant 1 (PF4V1)


CXCL4L1; PF4var1; CXCL4V1; SCYB4V1; SCYB4-V1; CXCL4-V1; Chemokine(C-X-C-Motif)Ligand 4 Variant

Platelet Factor 4 Variant 1 (PF4V1)

The PF4V1 gene comprised 3 exons and 2 introns. Exon 1 coded for a 34-amino acid hydrophobic leader sequence that had 70% sequence homology with the leader sequence of PF4. Exon 2 coded for a 42-amino acid segment that was 100% identical with the corresponding segment of the mature PF4 sequence. Exon 3 coded for the 28-residue carboxy-terminal region corresponding to a domain specifying heparin-binding and cellular chemotaxis. Human Gene Mapping Workshop 10.5 assigned the PF4V1 gene to 4q12-q21, the same region as that which carries the PF4, IP10, and MGSA genes. Green et al. (1989) suggested that the polymorphism detected in the PF4 gene by Guzzo et al. (1987) was in fact a polymorphism of the PF4V1 gene. Poncz et al. (1991) demonstrated that the PF4V1 and beta-thromboglobulin genes are located in a region of less than 190 kb.

Organism species: Homo sapiens (Human)

Proteins RPB568Hu01 Recombinant Platelet Factor 4 Variant 1 (PF4V1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB568Hu01 Polyclonal Antibody to Platelet Factor 4 Variant 1 (PF4V1) WB; IHC; ICC; IP.
MAB568Hu22 Monoclonal Antibody to Platelet Factor 4 Variant 1 (PF4V1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Platelet Factor 4 Variant 1 (PF4V1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Platelet Factor 4 Variant 1 (PF4V1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of PF4var1, a human gene variant of platelet factor 4."Mol. Cell. Biol. 9:1445-1451(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Structural and functional comparison of the genes for human platelet factor 4 and PF4alt."Blood 76:336-344(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis."Circ. Res. 95:855-857(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1."J. Biol. Chem. 288:13522-13533(2013) [PubMed] [Europe PMC] [Abstract]