Lymphocyte Function Associated Antigen 1 Alpha (CD11a)

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LFA1a; ITG-AL; LFA-1; LFA1-A; ITGAL; Integrin,Alpha L; CD11 antigen-like family member A; Leukocyte function-associated molecule 1 alpha chain

Lymphocyte Function Associated Antigen 1 Alpha (CD11a)

Integrin, alpha L is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3, and also functions in lymphocyte costimulatory signaling.CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB572Hu01 Recombinant Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB572Hu01 Polyclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
MAB572Hu22 Monoclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
Assay Kits SEB572Hu ELISA Kit for Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB572Mu01 Recombinant Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Positive Control; Immunogen; SDS-PAGE; WB.
RPB572Mu02 Recombinant Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB572Mu01 Polyclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
PAB572Mu02 Polyclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
Assay Kits SEB572Mu ELISA Kit for Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB572Ra01 Recombinant Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB572Ra01 Polyclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
MAB572Ra21 Monoclonal Antibody to Lymphocyte Function Associated Antigen 1 Alpha (CD11a) WB; IHC; ICC; IP.
Assay Kits SEB572Ra ELISA Kit for Lymphocyte Function Associated Antigen 1 Alpha (CD11a) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily."J. Cell Biol. 108:703-712(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene."Proc. Natl. Acad. Sci. U.S.A. 90:5364-5368(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter."J. Biol. Chem. 268:19305-19311(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter."Proc. Natl. Acad. Sci. U.S.A. 90:4221-4225(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin."Proc. Natl. Acad. Sci. U.S.A. 92:10277-10281(1995) [PubMed] [Europe PMC] [Abstract]
  10. "The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin."Structure 4:931-942(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain."J. Mol. Biol. 292:1-9(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation."Cell 112:99-111(2003) [PubMed] [Europe PMC] [Abstract]