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Tyrosine Kinase 2 (Tyk2)

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JTK1; Non-Receptor Tyrosine-Protein Kinase TYK2

Tyrosine Kinase 2 (Tyk2)
CCC B595
HGNC 12440
MGI 1929470
PubMed 18683816
UniProt P29597
Wiki TYK2

Non-receptor tyrosine-protein kinase TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity.

Cytokines play pivotal roles in immunity and inflammation by regulating the survival, proliferation, differentiation and function of immune cells as well as cells from other organ systems. Hence, targeting cytokines and their receptors is an effective means of treating such disorders. Type I and II cytokine receptors associate with Janus family kinases (JAKs) to effect intracellular signaling.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB595Hu01 Recombinant Tyrosine Kinase 2 (Tyk2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB595Hu01 Polyclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; ICC; IHC-P; IHC-F; ELISA.
MAB595Hu22 Monoclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB; IHC; ICC; IP.
Assay Kits SEB595Hu ELISA Kit for Tyrosine Kinase 2 (Tyk2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB595Mu01 Recombinant Tyrosine Kinase 2 (Tyk2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB595Mu01 Polyclonal Antibody to Tyrosine Kinase 2 (Tyk2) WB
Assay Kits n/a CLIA Kit for Tyrosine Kinase 2 (Tyk2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Kinase 2 (Tyk2) ELISA Kit Customized Service Offer
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A protein tyrosine kinase in the interferon alpha/beta signaling pathway."Cell 70:313-322(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and chromosomal mapping of new human tyrosine kinase genes."Oncogene 5:277-282(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Putative tyrosine kinases expressed in K-562 human leukemia cells."Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase."Mol. Cell. Biol. 14:8133-8142(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules."J. Biol. Chem. 279:43168-43177(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity." Immunity 25:745-755(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6."J. Mol. Biol. 400:413-433(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]