Interleukin 10 Receptor Beta (IL10Rb)

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CDW210b; CD210-B; IL10R-B; IL10-RB; CRF2-4; CRFB4; IL-10R2; Interleukin-10 receptor subunit 2

Interleukin 10 Receptor Beta (IL10Rb)

Interleukin 10 receptor, beta subunit belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.Gibbs and Pennica (1997) also cloned IL10RB by exon trapping of YAC clones spanning the interferon receptor region. The IL10RB cDNA encodes a 325-amino acid protein. Northern blot analysis revealed expression of a 2.0-kb transcript in all tissues tested except brain. Gibbs and Pennica (1997) used the human sequence to obtain the mouse cDNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB638Hu01 Recombinant Interleukin 10 Receptor Beta (IL10Rb) Positive Control; Immunogen; SDS-PAGE; WB.
APB638Hu01 Active Interleukin 10 Receptor Beta (IL10Rb) Cell culture; Activity Assays.
EPB638Hu61 Eukaryotic Interleukin 10 Receptor Beta (IL10Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB638Hu01 Polyclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
LAB638Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC.
MAB638Hu21 Monoclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
MAB638Hu22 Monoclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
Assay Kits SEB638Hu ELISA Kit for Interleukin 10 Receptor Beta (IL10Rb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB638Mu01 Recombinant Interleukin 10 Receptor Beta (IL10Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB638Mu01 Polyclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
LAB638Mu81 FITC-Linked Polyclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Interleukin 10 Receptor Beta (IL10Rb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 10 Receptor Beta (IL10Rb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB638Ra01 Recombinant Interleukin 10 Receptor Beta (IL10Rb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB638Ra01 Polyclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
MAB638Ra21 Monoclonal Antibody to Interleukin 10 Receptor Beta (IL10Rb) WB; IHC; ICC; IP.
Assay Kits SEB638Ra ELISA Kit for Interleukin 10 Receptor Beta (IL10Rb) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR."Genomics 16:366-373(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the human CRFB4 gene: comparison with its IFNAR neighbor."J. Mol. Evol. 41:338-344(1995) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and functional characterization of a second chain of the interleukin-10 receptor complex."EMBO J. 16:5894-5903(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
  7. "IL-28, IL-29 and their class II cytokine receptor IL-28R." Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence."Proc. Natl. Acad. Sci. U.S.A. 103:9148-9153(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Inflammatory bowel disease and mutations affecting the interleukin-10 receptor." N. Engl. J. Med. 361:2033-2045(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Structure and mechanism of receptor sharing by the IL-10R2 common chain."Structure 18:638-648(2010) [PubMed] [Europe PMC] [Abstract]