Phosphoglycerate Mutase 2, Muscle (PGAM2)

[Edit]

PGAM-M; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M

Phosphoglycerate Mutase 2, Muscle (PGAM2)
The function of PGAM2 : Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. It can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.In mammals, the enzyme subunits appear to be either a muscle-derived form (m-type) or other tissue (b-type for brain where the b-isozyme was originally isolated). Existing as a dimer, the enzyme then has 3 isozymes depending on which subunit forms makeup the whole molecule (mm, bb or mb). The mm-type is found mainly in smooth muscle almost exclusively. The mb-isozyme is found in cardiac and skeletal muscle and the bb-type is found in the rest of tissues. While all three isozymes may be found in any tissue, the above distributions are based on prevalence in each.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB645Hu01Recombinant Phosphoglycerate Mutase 2, Muscle (PGAM2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB645Hu01Polyclonal Antibody to Phosphoglycerate Mutase 2, Muscle (PGAM2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB645Mu01Recombinant Phosphoglycerate Mutase 2, Muscle (PGAM2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB645Mu01Polyclonal Antibody to Phosphoglycerate Mutase 2, Muscle (PGAM2)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphoglycerate Mutase 2, Muscle (PGAM2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphoglycerate Mutase 2, Muscle (PGAM2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphoglycerate Mutase 2, Muscle (PGAM2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphoglycerate Mutase 2, Muscle (PGAM2)ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the gene encoding the muscle-specific isozyme of human phosphoglycerate mutase."Gene 91:225-232(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Structure of the gene encoding the muscle-specific subunit of human phosphoglycerate mutase."J. Biol. Chem. 264:15334-15337(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of a cDNA encoding the muscle-specific subunit of human phosphoglycerate mutase."J. Biol. Chem. 262:14612-14617(1987) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency."Am. J. Hum. Genet. 52:472-477(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene."Neuromuscul. Disord. 9:399-402(1999) [PubMed] [Europe PMC] [Abstract]