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Interleukin 28A (IL28A)

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IFNL2; Interferon,Lambda 2; Cytokine Zcyto20

Interleukin 28A (IL28A)
CCC B689
HGNC 18364
MGI 3647279
PubMed 22560878
UniProt Q8IZJ0
Wiki Interleukin_28

  • Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29.

  • Interleukin-28A (IL-28A) is a novel cytokine discovered in recent years and has been shown to have antiviral activity. IL-28A, IL-28B and IL-29 are a family of class II cytokines that stimulate antiviral responses through a heterodimeric receptor that is distinct from the type I interferon (IFN) receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB689Hu01 Recombinant Interleukin 28A (IL28A) Positive Control; Immunogen; SDS-PAGE; WB.
APB689Hu01 Active Interleukin 28A (IL28A) Cell culture; Activity Assays.
Antibodies PAB689Hu01 Polyclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
MAB689Hu22 Monoclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
MAB689Hu21 Monoclonal Antibody to Interleukin 28A (IL28A) WB,IHC
MAB689Hu24 Monoclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
MAB689Hu26 Monoclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
LAB689Hu76 Biotin-Linked Monoclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC.
Assay Kits SEB689Hu ELISA Kit for Interleukin 28A (IL28A) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB689Hu CLIA Kit for Interleukin 28A (IL28A) Chemiluminescent immunoassay for Antigen Detection.
HEB689Hu High Sensitive ELISA Kit for Interleukin 28A (IL28A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB689Mu01 Recombinant Interleukin 28A (IL28A) Positive Control; Immunogen; SDS-PAGE; WB.
RPB689Mu02 Recombinant Interleukin 28A (IL28A) Positive Control; Immunogen; SDS-PAGE; WB.
EPB689Mu61 Eukaryotic Interleukin 28A (IL28A) Positive Control; Immunogen; SDS-PAGE; WB.
APB689Mu61 Active Interleukin 28A (IL28A) Cell culture; Activity Assays.
Antibodies PAB689Mu01 Polyclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
PAB689Mu02 Polyclonal Antibody to Interleukin 28A (IL28A) WB; IHC; ICC; IP.
Assay Kits SEB689Mu ELISA Kit for Interleukin 28A (IL28A) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB689Mu CLIA Kit for Interleukin 28A (IL28A) Chemiluminescent immunoassay for Antigen Detection.
  1. "IL-28, IL-29 and their class II cytokine receptor IL-28R." Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication."Virol. J. 2:80-80(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Interferon-lambda: a new addition to an old family."J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]