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Interleukin-25 (IL-25) is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells. It is also known as IL-17E. IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils.
This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB694Hu01 | Recombinant Interleukin 25 (IL25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB694Hu01 | Active Interleukin 25 (IL25) | Cell culture; Activity Assays. | |
| EPB694Hu61 | Eukaryotic Interleukin 25 (IL25) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB694Hu61 | Active Interleukin 25 (IL25) | Cell culture; Activity Assays. | |
| Antibodies | PAB694Hu01 | Polyclonal Antibody to Interleukin 25 (IL25) | WB; IHC; ICC; IP. |
| MAB694Hu22 | Monoclonal Antibody to Interleukin 25 (IL25) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB694Hu | ELISA Kit for Interleukin 25 (IL25) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB694Hu | CLIA Kit for Interleukin 25 (IL25) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB694Mu01 | Recombinant Interleukin 25 (IL25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB694Mu02 | Recombinant Interleukin 25 (IL25) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB694Mu01 | Polyclonal Antibody to Interleukin 25 (IL25) | WB; IHC; ICC; IP. |
| PAB694Mu02 | Polyclonal Antibody to Interleukin 25 (IL25) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB694Mu | ELISA Kit for Interleukin 25 (IL25) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB694Mu | CLIA Kit for Interleukin 25 (IL25) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB694Ra01 | Recombinant Interleukin 25 (IL25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB694Ra61 | Active Interleukin 25 (IL25) | Cell culture; Activity Assays. | |
| Antibodies | PAB694Ra01 | Polyclonal Antibody to Interleukin 25 (IL25) | WB,IHC |
| MAB694Ra21 | Monoclonal Antibody to Interleukin 25 (IL25) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB694Ra | ELISA Kit for Interleukin 25 (IL25) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB694Ra | CLIA Kit for Interleukin 25 (IL25) | Chemiluminescent immunoassay for Antigen Detection. |
- "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1."J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract]
- "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo."Immunity 15:985-995(2001) [PubMed] [Europe PMC] [Abstract]
- "Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production."Blood 100:2330-2340(2002) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]