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Bone Morphogenetic Protein 9 (BMP9)

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GDF2; Growth Differentiation Factor 2

Bone Morphogenetic Protein 9 (BMP9)
CCC B728
HGNC 4217
MGI 1321394
PubMed 23741013
RGD 1586196
UniProt Q9UK05
Wiki GDF2

Growth differentiation factor 2 (GDF2) is a protein also known as bone morphogenetic protein (BMP)-9 that belongs to the transforming growth factor beta superfamily. It has a role in inducing and maintaining the ability of embryonic basal forebrain cholinergic neurons (BFCN) to respond to a neurotransmitter called acetylcholine; BFCN are important for the processes of learning, memory and attention. GDF2 is also important for the maturation of BFCN.

Another role of GDF2 has been recently suggested. GDF2 is a potent inducer of hepcidin  in liver cells (hepatocytes) and can regulate iron metabolism. The physiological receptor of GDF2 is thought to be activin receptor-like kinase 1, ALK1 (also called ACVRL1), an endothelial-specific type I receptor of the TGF-beta receptor family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB728Hu01 Recombinant Bone Morphogenetic Protein 9 (BMP9) Positive Control; Immunogen; SDS-PAGE; WB.
RPB728Hu02 Recombinant Bone Morphogenetic Protein 9 (BMP9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB728Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
MAB728Hu22 Monoclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
LAB728Hu71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC.
LAB728Hu81 FITC-Linked Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IF.
PAB728Hu02 Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
Assay Kits SEB728Hu ELISA Kit for Bone Morphogenetic Protein 9 (BMP9) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB728Hu CLIA Kit for Bone Morphogenetic Protein 9 (BMP9) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB728Mu01 Recombinant Bone Morphogenetic Protein 9 (BMP9) Positive Control; Immunogen; SDS-PAGE; WB.
RPB728Mu02 Recombinant Bone Morphogenetic Protein 9 (BMP9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB728Mu01 Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
PAB728Mu02 Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
Assay Kits SEB728Mu ELISA Kit for Bone Morphogenetic Protein 9 (BMP9) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB728Mu CLIA Kit for Bone Morphogenetic Protein 9 (BMP9) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB728Ra01 Recombinant Bone Morphogenetic Protein 9 (BMP9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB728Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
MAB728Ra21 Monoclonal Antibody to Bone Morphogenetic Protein 9 (BMP9) WB; IHC; ICC; IP.
Assay Kits SEB728Ra ELISA Kit for Bone Morphogenetic Protein 9 (BMP9) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB728Ra CLIA Kit for Bone Morphogenetic Protein 9 (BMP9) Chemiluminescent immunoassay for Antigen Detection.
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  9. "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."J. Biol. Chem. 287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]
  10. "BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia."Am. J. Hum. Genet. 93:530-537(2013) [PubMed] [Europe PMC] [Abstract]