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Signal Transducer And Activator Of Transcription 6 (STAT6)

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IL-4-STAT; STAT6B; STAT6C; Signal Transducer And Activator Of Transcription 6,Interleukin-4 Induced

Signal Transducer And Activator Of Transcription 6 (STAT6)
CCC B737
HGNC 11368
MGI 103034
PubMed 21442426
RGD 1309063
UniProt P42226
Wiki STAT6

STAT6 is  a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses.

It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB737Hu01 Recombinant Signal Transducer And Activator Of Transcription 6 (STAT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB737Hu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6) WB; IHC; ICC; IP.
MAB737Hu22 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6) WB; IHC; ICC; IP.
Assay Kits SEB737Hu ELISA Kit for Signal Transducer And Activator Of Transcription 6 (STAT6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB737Mu01 Recombinant Signal Transducer And Activator Of Transcription 6 (STAT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB737Mu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducer And Activator Of Transcription 6 (STAT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducer And Activator Of Transcription 6 (STAT6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB737Ra01 Recombinant Signal Transducer And Activator Of Transcription 6 (STAT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB737Ra01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6) WB; IHC
MAB737Ra21 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 6 (STAT6) WB; IHC; ICC; IP.
Assay Kits SEB737Ra ELISA Kit for Signal Transducer And Activator Of Transcription 6 (STAT6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "An interleukin-4-induced transcription factor: IL-4 Stat."Science 265:1701-1706(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors."Genomics 52:192-200(1998) [PubMed] [Europe PMC] [Abstract]
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  6. "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1."J. Biol. Chem. 277:36052-36060(2002) [PubMed] [Europe PMC] [Abstract]
  7. "T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6."Mol. Cell. Biol. 27:2166-2179(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain."J. Mol. Biol. 336:319-329(2004) [PubMed] [Europe PMC] [Abstract]