≡

C-Type Lectin Domain Family 4, Member C (CLEC4C)

[Edit]

CD303; CLECSF11,CLECSF7; HECL; DLEC; BDCA2; Blood dendritic cell antigen 2; C-type lectin superfamily member 7; Dendritic lectin

C-Type Lectin Domain Family 4, Member C (CLEC4C)
CCC B741
HGNC 13258
MGI 3588267
PubMed 21880719
UniProt Q8WTT0
Wiki CLEC4C

CLEC4C is a dendritic cell marker.By searching for sequences similar to mouse Nkcl, Fernandes et al. (2000) identified an EST clone isolated from a testis cDNA library that contained the full-length coding sequence for CLECSF11, which they designated HECL. The deduced 183-amino acid protein has a calculated molecular mass of 20 kD and contains a C-type carbohydrate recognition domain (CRD) and 3 putative N-glycosylation sites, but no transmembrane domain or signal peptide. HECL shares significant homology with members of the C-type lectin superfamily, and its CRD is mose similar to that of mouse Nkcl. The 4 cysteines responsible for the C-type CRD fold are perfectly conserved between HECL and mouse Nkcl. Immunolocalization of epitope-tagged HECL expressed in COS cells revealed a cytoplasmic localization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB741Hu01 Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB741Hu01 Polyclonal Antibody to C-Type Lectin Domain Family 4, Member C (CLEC4C) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 4, Member C (CLEC4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 4, Member C (CLEC4C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 4, Member C (CLEC4C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 4, Member C (CLEC4C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 4, Member C (CLEC4C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 4, Member C (CLEC4C) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 4, Member C (CLEC4C) ELISA Kit Customized Service Offer
  1. "Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells."Eur. J. Immunol. 31:2733-2740(2001) [PubMed] [Europe PMC] [Abstract]
  2. "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction."J. Exp. Med. 194:1823-1834(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12."Genomics 69:263-270(2000) [PubMed] [Europe PMC] [Abstract]