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Interferon Regulatory Factor 4 (IRF4)

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LSIRF; MUM1; NF-EM5; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1

Interferon Regulatory Factor 4 (IRF4)
CCC B755
HGNC 6119
MGI 1096873
PubMed 24591370
RGD 1308050
UniProt Q15306
Wiki IRF4

By fluorescence and confocal microscopy, Negishi et al. (2005) demonstrated that IRF4 interacted with MYD88  in the cytoplasm of human embryonic kidney cells. Mutation and coimmunoprecipitation analysis showed that IRF4 interacted with the TIR/IL1 region of MYD88.

IRF4 inhibited interaction of MYD88 with IRF5, which interacts with the same central region of MYD88 as IRF4, but it did not block interaction of MYD88 with IRF7 , which binds to the N terminus. IRF5-dependent gene induction was inhibited by IRF4, and IRF4-deficient macrophages were hyperresponsive to Toll-like receptor (TLR) stimuli. Negishi et al. (2005) concluded that IRF4 negatively regulates TLR signaling by selectively competing with IRF5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 4 (IRF4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 4 (IRF4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 4 (IRF4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 4 (IRF4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 4 (IRF4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB755Mu01 Recombinant Interferon Regulatory Factor 4 (IRF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB755Mu01 Polyclonal Antibody to Interferon Regulatory Factor 4 (IRF4) WB; IHC; ICC; IP.
Assay Kits SEB755Mu ELISA Kit for Interferon Regulatory Factor 4 (IRF4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB755Ra01 Recombinant Interferon Regulatory Factor 4 (IRF4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB755Ra01 Polyclonal Antibody to Interferon Regulatory Factor 4 (IRF4) WB; IHC; ICC; IP.
MAB755Ra21 Monoclonal Antibody to Interferon Regulatory Factor 4 (IRF4) WB; IHC; ICC; IP.
Assay Kits SEB755Ra ELISA Kit for Interferon Regulatory Factor 4 (IRF4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25."Genomics 37:229-233(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma."Nat. Genet. 17:226-230(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."J. Biol. Chem. 274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system."Hum. Immunol. 64:389-401(2003) [PubMed] [Europe PMC] [Abstract]
  7. "A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation."PLoS Genet. 4:E1000074-E1000074(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway." Cell 155:1022-1033(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the IRF domain of human interferon regulator factor 4."Submitted (OCT-2006) to the PDB data bank