Bone Marrow Stromal Cell Antigen 2 (BST2)

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CD317; Tetherin; HM1.24 antigen

Bone Marrow Stromal Cell Antigen 2 (BST2)
Tetherin is a type 2 integral membrane protein, with the N-terminus in the cytoplasm, one membrane spanning domain, and a C-terminus modified by the addition of a glycosyl-phosphatidylinositol (gpi) anchor. When the virion buds from the surface of the cell, one of the tetherin membrane domains is in the new viral membrane, the other remains in the plasma membrane, tethering the virion to the cell. It is antagonized by the viral protein Vpu which is thought to work by targetting tetherin for degredation via the β-TrCP2 dependent pathway.
Tetherin exists as a dimer on the surface of cells, and prevention of dimerisation by mutating the cystine residues, prevents tetherin from inhibiting virus release, although it is still detectable in the cell.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB777Hu01Recombinant Bone Marrow Stromal Cell Antigen 2 (BST2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB777Hu01Polyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)WB, ICC, IHC-P, IHC-F, ELISA
MAB777Hu22Monoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB777HuELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bone Marrow Stromal Cell Antigen 2 (BST2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2)CLIA Kit Customized Service Offer
n/aELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Bone Marrow Stromal Cell Antigen 2 (BST2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Bone Marrow Stromal Cell Antigen 2 (BST2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2)CLIA Kit Customized Service Offer
n/aELISA Kit for Bone Marrow Stromal Cell Antigen 2 (BST2)ELISA Kit Customized Service Offer
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  20. "Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin."J. Virol. 84:10569-10580(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms."J. Virol. 84:12646-12657(2010) [PubMed] [Europe PMC] [Abstract]
  22. "The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin."PLoS Pathog. 6:E1000843-E1000843(2010) [PubMed] [Europe PMC] [Abstract]
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  26. "The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?"J. Interferon Cytokine Res. 31:137-144(2011) [PubMed] [Europe PMC] [Abstract]
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  29. "Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin."Virology 417:50-56(2011) [PubMed] [Europe PMC] [Abstract]
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  31. "Vpu and BST2: still not there yet?"Front. Microbiol. 3:131-131(2012) [PubMed] [Europe PMC] [Abstract]
  32. "BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity."J. Cell. Biochem. 113:1013-1021(2012) [PubMed] [Europe PMC] [Abstract]
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  34. "Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities."PLoS Pathog. 8:E1002931-E1002931(2012) [PubMed] [Europe PMC] [Abstract]
  35. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
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