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Signal Transducer And Activator Of Transcription 2 (STAT2)

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ISGF-3; P113; STAT113

Signal Transducer And Activator Of Transcription 2 (STAT2)
CCC B796
HGNC 11363
MGI 103039
PubMed 23391734
RGD 1311649
UniProt P52630
Wiki STAT2

Signal transducer and activator of transcription 2 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly.

Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB796Hu01 Recombinant Signal Transducer And Activator Of Transcription 2 (STAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB796Hu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 2 (STAT2) WB; IHC; ICC; IP.
MAB796Hu22 Monoclonal Antibody to Signal Transducer And Activator Of Transcription 2 (STAT2) WB; IHC; ICC; IP.
Assay Kits SEB796Hu ELISA Kit for Signal Transducer And Activator Of Transcription 2 (STAT2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB796Mu01 Recombinant Signal Transducer And Activator Of Transcription 2 (STAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB796Mu01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 2 (STAT2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Signal Transducer And Activator Of Transcription 2 (STAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Signal Transducer And Activator Of Transcription 2 (STAT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB796Ra01 Recombinant Signal Transducer And Activator Of Transcription 2 (STAT2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB796Ra01 Polyclonal Antibody to Signal Transducer And Activator Of Transcription 2 (STAT2) WB; IHC; ICC; IP.
Assay Kits SEB796Ra ELISA Kit for Signal Transducer And Activator Of Transcription 2 (STAT2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction."Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2."Nucleic Acids Res. 23:459-463(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)."Cell 70:323-335(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Role of STAT2 in the alpha interferon signaling pathway."Mol. Cell. Biol. 15:1312-1317(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of alternative splicing form of Stat2."FEBS Lett. 381:191-194(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA."J. Biol. Chem. 272:4600-4605(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling."Mol. Cell. Biol. 17:2048-2056(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Viral inhibition of interferon signal transduction."Intervirology 42:325-330(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs."J. Biol. Chem. 276:16447-16455(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Role of metazoan mediator proteins in interferon-responsive transcription."Mol. Cell. Biol. 23:620-628(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1."J. Virol. 79:13434-13441(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO."J. Virol. 82:10444-10454(2008) [PubMed] [Europe PMC] [Abstract]
  16. "NS5 of dengue virus mediates STAT2 binding and degradation."J. Virol. 83:5408-5418(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation."J. Infect. Dis. 200:1261-1270(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses."J. Biol. Chem. 288:747-758(2013) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]