Coagulation Factor VIII (F8)

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FVIII; AHF; HEMA; F8B; F8C; Antihemophilic Globulin; Hemophilia A; Anti-Hemophilic Factor A; FVIII Procoagulant Component; F8 Protein

Coagulation Factor VIII (F8)
Factor VIII (FVIII) is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene. Defects in this gene results in hemophilia A, a well known recessive X-linked coagulation disorder.
Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids forms a complex that converts factor X to the activated form Xa. The Factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB878Hu01Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
RPB878Hu02Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAB878Hu01Polyclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
MAB878Hu22Monoclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
PAB878Hu02Polyclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
LAB878Hu71Biotin-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)IHC;WB;ELISA
LAB878Hu81FITC-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)IHC;ICC;IF;WB
LAB878Hu83FITC-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)WB; ICC; IHC-P; IHC-F; IF; ELISA.
LAB878Hu73Biotin-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay KitsSEB878HuELISA Kit for Coagulation Factor VIII (F8)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB878Mu01Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP.
RPB878Mu02Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB878Mu01Polyclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
LAB878Mu81FITC-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)IHC;ICC;IF;WB
LAB878Mu71Biotin-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)IHC;WB;ELISA
PAB878Mu02Polyclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB878MuELISA Kit for Coagulation Factor VIII (F8)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Coagulation Factor VIII (F8)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Coagulation Factor VIII (F8)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Coagulation Factor VIII (F8)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Coagulation Factor VIII (F8)CLIA Kit Customized Service Offer
n/aELISA Kit for Coagulation Factor VIII (F8)ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB878Ca01Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB878Ca01Polyclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
MAB878Ca21Monoclonal Antibody to Coagulation Factor VIII (F8)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB878CaELISA Kit for Coagulation Factor VIII (F8)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB878Po01Recombinant Coagulation Factor VIII (F8)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
AntibodiesPAB878Po01Polyclonal Antibody to Coagulation Factor VIII (F8)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAB878Po81FITC-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)IHC;ICC;IF;WB
LAB878Po71Biotin-Linked Polyclonal Antibody to Coagulation Factor VIII (F8)WB; ICC; IHC-P; IHC-F; IF; ELISA.
Assay Kitsn/aCLIA Kit for Coagulation Factor VIII (F8)CLIA Kit Customized Service Offer
n/aELISA Kit for Coagulation Factor VIII (F8)ELISA Kit Customized Service Offer
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  82. ErratumThromb. Haemost. 86:727-727(2001)
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  95. "Mutation analysis in 51 patients with haemophilia A: report of 10 novel mutations and correlations between genotype and clinical phenotype."Haemophilia 11:133-141(2005) [PubMed] [Europe PMC] [Abstract]
  96. "Female haemophilia A heterozygous for a de novo frameshift and a novel missense mutation of factor VIII."J. Thromb. Haemost. 4:1969-1974(2006) [PubMed] [Europe PMC] [Abstract]
  97. "Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites."Blood 111:3468-3478(2008) [PubMed] [Europe PMC] [Abstract]
  98. "Identification of factor VIII gene mutations in patients with severe haemophilia A in Venezuela: identification of seven novel mutations."Haemophilia 17:913-918(2011) [PubMed] [Europe PMC] [Abstract]
  99. "Factor VIII Antigen, Activity, and Mutations in Hemophilia A."Clin. Appl. Thromb. Hemost. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]