Wiskott Aldrich Syndrome Protein (WASP)


WAS; IMD2; THC; Eczema-Thrombocytopenia

Wiskott Aldrich Syndrome Protein (WASP)
The Wiskott-Aldrich Syndrome Protein (WASp) is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon Cdc42 and PIP2 acting to disrupt this interaction causing the WASp protein to 'open'.
This exposes a domain near the WASp C-Terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin. WASp is the founding member of a gene family which also includes the broadly expressed N-WASP (neuronal Wiskott-Aldrich Syndrome protein), and Scar.

Organism species: Homo sapiens (Human)

Proteins RPB917Hu01 Recombinant Wiskott Aldrich Syndrome Protein (WASP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB917Hu01 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

Proteins n/a Recombinant Wiskott Aldrich Syndrome Protein (WASP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) ELISA Kit Customized Service Offer
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