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Wiskott Aldrich Syndrome Protein (WASP)

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WAS; IMD2; THC; Eczema-Thrombocytopenia

Wiskott Aldrich Syndrome Protein (WASP)
CCC B917
HGNC 12731
MGI 105059
PubMed 10724160
UniProt P42768
Wiki WASP
The Wiskott-Aldrich Syndrome Protein (WASp) is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon Cdc42 and PIP2 acting to disrupt this interaction causing the WASp protein to 'open'.
This exposes a domain near the WASp C-Terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin. WASp is the founding member of a gene family which also includes the broadly expressed N-WASP (neuronal Wiskott-Aldrich Syndrome protein), and Scar.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB917Hu01 Recombinant Wiskott Aldrich Syndrome Protein (WASP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB917Hu01 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) WB,IHC
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Wiskott Aldrich Syndrome Protein (WASP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB917Ra01 Recombinant Wiskott Aldrich Syndrome Protein (WASP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB917Ra01 Polyclonal Antibody to Wiskott Aldrich Syndrome Protein (WASP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Wiskott Aldrich Syndrome Protein (WASP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Wiskott Aldrich Syndrome Protein (WASP) ELISA Kit Customized Service Offer
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  9. "WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells."Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997) [PubMed] [Europe PMC] [Abstract]
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  11. "Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP."Mol. Cell 11:1229-1239(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation."J. Exp. Med. 199:99-112(2004) [PubMed] [Europe PMC] [Abstract]
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  23. "Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U)."Nature 454:1009-1013(2008) [PubMed] [Europe PMC] [Abstract]
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  25. "WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia."Hum. Mol. Genet. 4:1127-1135(1995) [PubMed] [Europe PMC] [Abstract]
  26. "X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene."Nat. Genet. 9:414-417(1995) [PubMed] [Europe PMC] [Abstract]
  27. "Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product."Hum. Genet. 98:68-76(1996) [PubMed] [Europe PMC] [Abstract]
  28. "Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients."J. Immunol. 158:4021-4025(1997) [PubMed] [Europe PMC] [Abstract]
  29. "Mutation analysis of five Japanese families with Wiskott-Aldrich syndrome and determination of the family members' carrier status using three different methods."Pediatr. Res. 41:535-540(1997) [PubMed] [Europe PMC] [Abstract]
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