Neurofibromin 2 (NF2)


ACN; BANF; SCH; Merlin; Bilateral Acoustic Neuroma; Schwannomin; Schwannomerlin; Moesin-Ezrin-Radixin-Like Protein

Neurofibromin 2 (NF2)

Merlin is a cytoskeletal protein. In humans, it is a tumor suppressor protein involved in Neurofibromatosis type II.Sequence data reveal its similarity to the ERM protein family.The name "merlin" is an acronym for "Moesin-Ezrin-Radixin-Like Protein". Human merlin is coded by the gene NF2 in Chromosome 22. Mouse merlin gene is located on the chromosome 11 and rat merlin gene on the chromosome 17. Fruit fly merlin gene (symbol Mer) is located on chromosome 1 and shares 58% similarity to its human homologue. Other merlin-like genes are known from a wide range of animals, and the derivation of merlin is thought to be in early metazoa. Merlin is a member of the ERM family of proteins including ezrin, moesin, and radixin, which are in the protein 4.1 superfamily of proteins.

Organism species: Homo sapiens (Human)

ProteinsRPB946Hu01Recombinant Neurofibromin 2 (NF2)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAB946Hu01Polyclonal Antibody to Neurofibromin 2 (NF2)WB; IHC; ICC; IP.
MAB946Hu22Monoclonal Antibody to Neurofibromin 2 (NF2)WB; IHC; ICC; IP.
Assay KitsSEB946HuELISA Kit for Neurofibromin 2 (NF2)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPB946Mu01Recombinant Neurofibromin 2 (NF2)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAB946Mu01Polyclonal Antibody to Neurofibromin 2 (NF2)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Neurofibromin 2 (NF2)CLIA Kit Customized Service Offer
n/aELISA Kit for Neurofibromin 2 (NF2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

Proteinsn/aRecombinant Neurofibromin 2 (NF2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Neurofibromin 2 (NF2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Neurofibromin 2 (NF2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Neurofibromin 2 (NF2)CLIA Kit Customized Service Offer
n/aELISA Kit for Neurofibromin 2 (NF2)ELISA Kit Customized Service Offer
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  36. ErratumJ. Med. Genet. 36:87-87(1999)
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