Tar DNA Binding Protein 43kDa (TDP43)

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TARDBP; ALS10

Tar DNA Binding Protein 43kDa (TDP43)
TAR DNA-binding protein is a cellular factor of 43 kDa that binds specifically to pyrimidine-rich motifs in TAR. Antibody to TDP-43 was used in gel retardation assays to demonstrate that endogenous TDP-43, present in HeLa nuclear extract, also bound to TAR DNA.
Although TDP-43 bound strongly to double-stranded TAR DNA via its ribonucleoprotein protein- binding motifs, it did not bind to TAR RNA extending from 1 to 80. TDP-43 is capable of modulating both in vitro and in vivo HIV-1 gene expression by either altering or blocking the assembly of transcription complexes that are capable of responding to Tat.TDP-43 is the major disease protein in both disorders.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB951Hu01Recombinant Tar DNA Binding Protein 43kDa (TDP43)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB951Hu01Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB, ICC, IHC-P, IHC-F, ELISA
MAB951Hu22Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB951HuELISA Kit for Tar DNA Binding Protein 43kDa (TDP43)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB951Mu01Recombinant Tar DNA Binding Protein 43kDa (TDP43)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB951Mu01Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Tar DNA Binding Protein 43kDa (TDP43)CLIA Kit Customized Service Offer
n/aELISA Kit for Tar DNA Binding Protein 43kDa (TDP43)ELISA Kit Customized Service Offer
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  7. , Submitted (MAR-2007) to UniProtKB
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  9. "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping."EMBO J. 20:1774-1784(2001) [PubMed] [Europe PMC] [Abstract]
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  16. "Solution structure of the RNA binding domains of TAR DNA-binding protein-43."Submitted (NOV-2005) to the PDB data bank
  17. "Solution structure of RRM domain in tar DNA-binding protein-43."Submitted (FEB-2009) to the PDB data bank
  18. "TDP-43 A315T mutation in familial motor neuron disease."Ann. Neurol. 63:535-538(2008) [PubMed] [Europe PMC] [Abstract]
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  22. "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis."Science 319:1668-1672(2008) [PubMed] [Europe PMC] [Abstract]
  23. "TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration."Ann. Neurol. 65:470-473(2009) [PubMed] [Europe PMC] [Abstract]
  24. "High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis."Hum. Mutat. 30:688-694(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease."Hum. Mutat. 30:E974-E983(2009) [PubMed] [Europe PMC] [Abstract]
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  27. "Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene." Arch. Neurol. 68:594-598(2011) [PubMed] [Europe PMC] [Abstract]
  28. "High frequency of the TARDBP p.Ala382Thr mutation in Sardinian patients with amyotrophic lateral sclerosis."Clin. Genet. 81:172-178(2012) [PubMed] [Europe PMC] [Abstract]
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