Tar DNA Binding Protein 43kDa (TDP43)

TAR DNA-binding protein is a cellular factor of 43 kDa that binds specifically to pyrimidine-rich motifs in TAR. Antibody to TDP-43 was used in gel retardation assays to demonstrate that endogenous TDP-43, present in HeLa nuclear extract, also bound to TAR DNA.

Although TDP-43 bound strongly to double-stranded TAR DNA via its ribonucleoprotein protein- binding motifs, it did not bind to TAR RNA extending from 1 to 80. TDP-43 is capable of modulating both in vitro and in vivo HIV-1 gene expression by either altering or blocking the assembly of transcription complexes that are capable of responding to Tat.TDP-43 is the major disease protein in both disorders.

Organism species: Homo sapiens (Human)

ProteinsRPB951Hu01Recombinant Tar DNA Binding Protein 43kDa (TDP43)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAB951Hu01Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB; IHC; ICC; IP.
MAB951Hu22Monoclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB; IHC; ICC; IP.
Assay KitsSEB951HuELISA Kit for Tar DNA Binding Protein 43kDa (TDP43)Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

ProteinsRPB951Mu01Recombinant Tar DNA Binding Protein 43kDa (TDP43)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAB951Mu01Polyclonal Antibody to Tar DNA Binding Protein 43kDa (TDP43)WB; IHC; ICC; IP.
Assay Kitsn/aCLIA Kit for Tar DNA Binding Protein 43kDa (TDP43)CLIA Kit Customized Service Offer
n/aELISA Kit for Tar DNA Binding Protein 43kDa (TDP43)ELISA Kit Customized Service Offer
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  7. , Submitted (MAR-2007) to UniProtKB
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  17. "Solution structure of RRM domain in tar DNA-binding protein-43."Submitted (FEB-2009) to the PDB data bank
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