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Hemopexin (HPX)

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Haemopexin; Beta-1B-glycoprotein

Hemopexin (HPX)
CCC B986
HGNC 5171
MGI 105112
PubMed 19650691
RGD 62040
UniProt P02790
Wiki Hemopexin

hemopexin (or haemopexin) binds heme with the highest affinity of any known protein. Its function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin and thus protects the body from the oxidative damage that free heme can cause. In addition, hemopexin releases its bound ligand for internalisation upon interacting with a specific receptor situated on the surface of liver cells. This function of hemopexin is to preserve the body's iron. Its levels in serum reflect how much heme is present in the blood. Therefore, high hemopexin levels indicates that there has been significant degradation of heme containing compounds and hemopexin is made to scavenge any heme it can. High hemopexin levels are therefore one of the diagnostic features of a hemolytic anemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB986Hu01 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
RPB986Hu02 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
RPB986Hu03 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB986Hu01 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Hu22 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
PAB986Hu02 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
LAB986Hu71 Biotin-Linked Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC.
PAB986Hu03 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Hu21 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Hu23 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Hu25 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
Assay Kits SEB986Hu ELISA Kit for Hemopexin (HPX) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB986Hu CLIA Kit for Hemopexin (HPX) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPB986Mu61 Eukaryotic Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB986Mu01 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Mu22 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
Assay Kits SEB986Mu ELISA Kit for Hemopexin (HPX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB986Ra01 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
RPB986Ra02 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB986Ra01 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
MAB986Ra22 Monoclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
PAB986Ra02 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
LAB986Ra71 Biotin-Linked Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC.
Assay Kits SEB986Ra ELISA Kit for Hemopexin (HPX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB986Bo01 Recombinant Hemopexin (HPX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB986Bo01 Polyclonal Antibody to Hemopexin (HPX) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hemopexin (HPX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemopexin (HPX) ELISA Kit Customized Service Offer
  1. "Structure of the human hemopexin gene and evidence for intron-mediated evolution."J. Mol. Evol. 27:102-108(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11."Genomics 3:48-52(1988) [PubMed] [Europe PMC] [Abstract]
  4. "The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology."Nucleic Acids Res. 13:3841-3859(1985) [PubMed] [Europe PMC] [Abstract]
  5. "Complete amino acid sequence of human hemopexin, the heme-binding protein of serum."Proc. Natl. Acad. Sci. U.S.A. 82:73-77(1985) [PubMed] [Europe PMC] [Abstract]
  6. "Amino acid sequence of the N-terminal region of human hemopexin."FEBS Lett. 178:213-216(1984) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues."Proc. Natl. Acad. Sci. U.S.A. 81:2021-2025(1984) [PubMed] [Europe PMC] [Abstract]
  8. "A proteomic analysis of human bile."Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II."Biochemistry 47:1957-1969(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin."J. Biol. Chem. 285:28874-28882(2010) [PubMed] [Europe PMC] [Abstract]
  17. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]