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Dihydropyrimidine Dehydrogenase (DPYD)

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DPD; DHPDHase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase

Dihydropyrimidine Dehydrogenase (DPYD)
CCC C012
HGNC 3012
MGI 2139667
PubMed 20920994
RGD 621218
UniProt Q12882
Wiki DPYD

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.The sequence of the gene suggested that DPD has at least 3 distinct domains: a possible NADPH binding site and FAD-binding site in the N terminus, 2 motifs of putative iron/sulfur-binding sites near the C terminus, and a peptide domain corresponding to the uracil-binding site.

Expression of the pig enzyme in E. coli catalyzed the reduction of uracil, thymine, and 5-fluorouracil (5FU) with kinetics approximating those published for the enzyme purified from mammalian liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC012Hu01 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC012Hu01 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB; IHC
MAC012Hu22 Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB; IHC; ICC; IP.
MAC012Hu21 Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB; IHC; ICC; IP.
Assay Kits SEC012Hu ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC012Mu01 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) Positive Control; Immunogen; SDS-PAGE; WB.
RPC012Mu02 Recombinant Dihydropyrimidine Dehydrogenase (DPYD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC012Mu01 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB; IHC; ICC; IP.
PAC012Mu02 Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) WB; IHC; ICC; IP.
Assay Kits SEC012Mu ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dihydropyrimidine Dehydrogenase (DPYD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dihydropyrimidine Dehydrogenase (DPYD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dihydropyrimidine Dehydrogenase (DPYD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dihydropyrimidine Dehydrogenase (DPYD) ELISA Kit Customized Service Offer
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  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
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  15. "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]