Aldehyde Dehydrogenase, Mitochondrial (ALDM)

[Edit]

ALDH2; ALDH-E2; ALDHI; Aldehyde Dehydrogenase 2

Aldehyde Dehydrogenase, Mitochondrial (ALDM)

Mitochondrial Aldehyde Dehydrogenase belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC024Hu01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC024Hu01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
MAC024Hu22 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
LAC024Hu71 Biotin-Linked Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC.
Assay Kits SEC024Hu ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC024Mu01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC024Mu01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC024Ra01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC024Ra01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
MAC024Ra21 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
Assay Kits SEC024Ra ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase."FEBS Lett. 215:233-236(1987) [PubMed] [Europe PMC] [Abstract]
  2. ErratumFEBS Lett. 233:440-440(1988)
  3. "Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase."Nucleic Acids Res. 15:3179-3179(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure of the human mitochondrial aldehyde dehydrogenase gene."Genomics 2:57-65(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations."Eur. J. Biochem. 153:13-28(1985) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2."Proc. Natl. Acad. Sci. U.S.A. 82:3771-3775(1985) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases."Alcohol 2:103-106(1985) [PubMed] [Europe PMC] [Abstract]
  11. , Submitted (MAR-2007) to UniProtKB
  12. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Human aldehyde dehydrogenase isozymes and alcohol sensitivity."Isozymes Curr. Top. Biol. Med. Res. 16:21-48(1987) [PubMed] [Europe PMC] [Abstract]
  14. "Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data."FEBS Lett. 222:95-98(1987) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms."Protein Sci. 8:2784-2790(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals."Proc. Natl. Acad. Sci. U.S.A. 81:258-261(1984) [PubMed] [Europe PMC] [Abstract]
  19. "Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles."Alcohol. Clin. Exp. Res. 19:1105-1110(1995) [PubMed] [Europe PMC] [Abstract]