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Peroxisome Proliferator Activated Receptor Delta (PPARd)

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FAAR; NR1C2; NUC1; NUCI; PPARB; PPARd/B; Nuclear Receptor Subfamily 1,Group C,Member 2; Nuclear hormone receptor 1; Peroxisome proliferator-activated receptor beta

Peroxisome Proliferator Activated Receptor Delta (PPARd)
CCC C041
HGNC 9235
MGI 101884
PubMed 21834910
RGD 3370
UniProt Q03181
Wiki PPARD

Peroxisome proliferator-activated receptor delta is a  member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.PPAR-delta/beta；is the main target of a chemical substance named GW 501516. Using this ligand as a research ligand, It has been shown that agonism of PPAR-delta changes the body's fuel preference from glucose to lipids. PPAR-delta/beta is highly expressed in colon, small intestine, liver and keratinocytes. In contrast, heart, spleen, skeletal muscle, lung, brain and thymus show low expression.

Knockout mice lacking the ligand binding domain of PPAR-delta/beta are viable. However these mice are smaller than the wild type both neo and postnatally. In addition, fat stores in the gonads of the mutants are smaller.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC041Hu01 Recombinant Peroxisome Proliferator Activated Receptor Delta (PPARd) Positive Control; Immunogen; SDS-PAGE; WB.
RPC041Hu02 Recombinant Peroxisome Proliferator Activated Receptor Delta (PPARd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC041Hu01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC; IP.
MAC041Hu22 Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC; IP.
PAC041Hu02 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC; IP.
LAC041Hu71 Biotin-Linked Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC.
Assay Kits SEC041Hu ELISA Kit for Peroxisome Proliferator Activated Receptor Delta (PPARd) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC041Mu01 Recombinant Peroxisome Proliferator Activated Receptor Delta (PPARd) Positive Control; Immunogen; SDS-PAGE; WB.
RPC041Mu02 Recombinant Peroxisome Proliferator Activated Receptor Delta (PPARd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC041Mu01 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC; IP.
LAC041Mu71 Biotin-Linked Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC.
PAC041Mu02 Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) WB; IHC; ICC; IP.
Assay Kits SEC041Mu ELISA Kit for Peroxisome Proliferator Activated Receptor Delta (PPARd) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisome Proliferator Activated Receptor Delta (PPARd) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisome Proliferator Activated Receptor Delta (PPARd) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisome Proliferator Activated Receptor Delta (PPARd) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisome Proliferator Activated Receptor Delta (PPARd) ELISA Kit Customized Service Offer
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  10. "3,4,5-trisubstituted isoxazoles as novel PPARdelta agonists. Part 2."Bioorg. Med. Chem. Lett. 16:5488-5492(2006) [PubMed] [Europe PMC] [Abstract]
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  12. "Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form."Mol. Cell 21:1-2(2006) [PubMed] [Europe PMC] [Abstract]
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  15. "Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures."Acta Crystallogr. D 65:786-795(2009) [PubMed] [Europe PMC] [Abstract]
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  17. "Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent." Proc. Natl. Acad. Sci. U.S.A. 106:262-267(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the C4-type zinc finger domain from human peroxisome proliferator-activated receptor delta."Submitted (APR-2008) to the PDB data bank