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Major Histocompatibility Complex Class I A (MHCA)

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HLA-A; HLAA; MHC-A; Leukocyte Antigen A; HLA class I histocompatibility antigen, A-31 alpha chain

Major Histocompatibility Complex Class I A (MHCA)
CCC C085
HGNC 4931
MGI 95904
PubMed 24244023
UniProt P16189
Wiki HLA-A
HLA-A is a component of certain MHC class I cell surface receptor isoforms that resides on the surface of all nucleated cells and platelets. The receptor is a heterodimer, and is composed of a heavy, α chain, and smaller beta (β) chain. The alpha chain is encoded by a variant HLA-A gene and the beta chain (β2-microglobulin) is composed by the invariant Beta-2 microglobulin gene.
For humans, as in most mammalian populations, MHC Class I molecules are extremely variable in their primary structure, and HLA-A is ranked among the genes in humans with the fastest evolving coding sequence. After typing millions of individuals, hundreds of variant alleles and isoforms have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC085Hu01 Recombinant Major Histocompatibility Complex Class I A (MHCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC085Hu01 Polyclonal Antibody to Major Histocompatibility Complex Class I A (MHCA) WB; IHC; ICC; IP.
MAC085Hu21 Monoclonal Antibody to Major Histocompatibility Complex Class I A (MHCA) WB; IHC; ICC; IP.
Assay Kits SEC085Hu ELISA Kit for Major Histocompatibility Complex Class I A (MHCA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class I A (MHCA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class I A (MHCA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class I A (MHCA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class I A (MHCA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class I A (MHCA) ELISA Kit Customized Service Offer
  1. "Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30."J. Immunol. 143:3371-3378(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Unusual HLA-B alleles in two tribes of Brazilian Indians."Nature 357:326-329(1992) [PubMed] [Europe PMC] [Abstract]
  3. "On the sequence of A*3101."Tissue Antigens 47:428-430(1996) [PubMed] [Europe PMC] [Abstract]
  4. "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci."Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Non-conservative substitutions distinguish previously uncharacterized HLA-A molecules."Tissue Antigens 57:95-102(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans." N. Engl. J. Med. 364:1134-1143(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]