Collagen Type VIII Alpha 1 (COL8a1)

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COL8-A1; Collagen Alpha-1(VIII)chain; Endothelial collagen; Vastatin

Collagen Type VIII Alpha 1 (COL8a1)

Collagen alpha-1(VIII) chain is one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same isoform have been observed.

Type VIII collagen may be unique among the collagens for its tissue distribution and biosynthetic properties. It was first detected and designated EC (endothelial cell) collagen in biosynthetic studies of bovine aortic endothelial cells and rabbit corneal endothelial cells, but not all endothelial cells synthesize type VIII collagen nor is the protein restricted to vascular endothelium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC146Hu01 Recombinant Collagen Type VIII Alpha 1 (COL8a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC146Hu01 Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
MAC146Hu22 Monoclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
Assay Kits SEC146Hu ELISA Kit for Collagen Type VIII Alpha 1 (COL8a1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC146Mu01 Recombinant Collagen Type VIII Alpha 1 (COL8a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC146Mu01 Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
LAC146Mu71 Biotin-Linked Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Collagen Type VIII Alpha 1 (COL8a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type VIII Alpha 1 (COL8a1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC146Ra01 Recombinant Collagen Type VIII Alpha 1 (COL8a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC146Ra01 Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
LAC146Ra71 Biotin-Linked Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Collagen Type VIII Alpha 1 (COL8a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type VIII Alpha 1 (COL8a1) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC146Rb01 Recombinant Collagen Type VIII Alpha 1 (COL8a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAC146Rb21 Monoclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
PAC146Rb51 Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Collagen Type VIII Alpha 1 (COL8a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type VIII Alpha 1 (COL8a1) ELISA Kit Customized Service Offer
  1. "The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3."Eur. J. Biochem. 197:615-622(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Distribution of type VIII collagen in tissues: an immunohistochemical study."Connect. Tissue Res. 24:303-318(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Cleavage of type VIII collagen by human neutrophil elastase."Biochim. Biophys. Acta 1139:295-299(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Human mast cells produce type VIII collagen in vivo."Int. J. Exp. Pathol. 75:397-404(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The alpha1(VIII) and alpha2(VIII) collagen chains form two distinct homotrimeric proteins in vivo."Matrix Biol. 19:19-28(2000) [PubMed] [Europe PMC] [Abstract]
  7. "NC1 domain of human type VIII collagen (alpha 1) inhibits bovine aortic endothelial cell proliferation and causes cell apoptosis."Biochem. Biophys. Res. Commun. 289:264-268(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers."J. Biol. Chem. 279:21469-21477(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Collagen type VIII expression in human diabetic nephropathy."Eur. J. Clin. Invest. 37:767-773(2007) [PubMed] [Europe PMC] [Abstract]