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Neurturin, a potent neurotrophic factor, was purified from Chinese hamster ovary cell-conditioned media by Kotzbauer et al. (1996). It is closely related to glial cell line-derived neurotrophic factor (GDNF). NRTN and GDNF form a distinct TGF-beta subfamily, referred to as TRNs (for 'TGF-beta-related neurotrophins'). GDNF is a ligand for the tyrosine kinase receptor RET. Signaling requires an additional GPI-linked protein, GDNF receptor-alpha (GDNFRA).
NRTN also signals through RET and a GPI-linked coreceptor. Like GDNF, neurturin can promote the survival of numerous neuronal populations, including sympathetic, nodose, and dorsal root ganglion sensory neurons. Heuckeroth et al. (1997) isolated mouse and human genomic neurturin clones.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC169Hu01 | Recombinant Neurturin (NRTN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC169Hu01 | Polyclonal Antibody to Neurturin (NRTN) | WB; IHC; ICC; IP. |
| MAC169Hu22 | Monoclonal Antibody to Neurturin (NRTN) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC169Hu | ELISA Kit for Neurturin (NRTN) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neurturin (NRTN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neurturin (NRTN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neurturin (NRTN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neurturin (NRTN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurturin (NRTN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neurturin (NRTN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neurturin (NRTN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neurturin (NRTN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neurturin (NRTN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neurturin (NRTN) | ELISA Kit Customized Service Offer |
- "Neurturin, a relative of glial-cell-line-derived neurotrophic factor."Nature 384:467-470(1996) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease."Hum. Mol. Genet. 7:1449-1452(1998) [PubMed] [Europe PMC] [Abstract]