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Axis Inhibition Protein 2 (AXIN2)

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Axil; Conductin; Axin Related Protein; Axin-like protein

Axis Inhibition Protein 2 (AXIN2)
CCC C192
HGNC 904
MGI 1270862
PubMed 19119171
RGD 69259
UniProt Q9Y2T1
Wiki AXIN2
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC192Hu01 Recombinant Axis Inhibition Protein 2 (AXIN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC192Hu01 Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) WB; IHC; ICC; IP.
MAC192Hu22 Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) WB; IHC; ICC; IP.
MAC192Hu21 Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) WB; IHC; ICC; IP.
Assay Kits SEC192Hu ELISA Kit for Axis Inhibition Protein 2 (AXIN2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Axis Inhibition Protein 2 (AXIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Axis Inhibition Protein 2 (AXIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Axis Inhibition Protein 2 (AXIN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Axis Inhibition Protein 2 (AXIN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Axis Inhibition Protein 2 (AXIN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Axis Inhibition Protein 2 (AXIN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Axis Inhibition Protein 2 (AXIN2) ELISA Kit Customized Service Offer
  1. "Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24."Genomics 55:341-344(1999) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling."Nat. Genet. 26:146-147(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer."Am. J. Hum. Genet. 74:1043-1050(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling." Nature 461:614-620(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
  9. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population."Int. J. Mol. Med. 18:279-284(2006) [PubMed] [Europe PMC] [Abstract]