Presenilin 1 (PSEN1)


FAD; AD3; PS1; PSNL1; S182; Alzheimer Disease 3; Protein S182; Presenilin-1 CTF12

Presenilin 1 (PSEN1)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma secretase activity or themselves are protease enzymes. Multiple alternatively spliced transcript variants have been identified for this gene, the full-length natures of only some have been determined.

Organism species: Homo sapiens (Human)

Proteins RPC200Hu01 Recombinant Presenilin 1 (PSEN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC200Hu01 Polyclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
MAC200Hu21 Monoclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
Assay Kits SEC200Hu ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

Proteins RPC200Mu01 Recombinant Presenilin 1 (PSEN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC200Mu02 Recombinant Presenilin 1 (PSEN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC200Mu01 Polyclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
PAC200Mu02 Polyclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
Assay Kits SEC200Mu ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

Proteins RPC200Ra01 Recombinant Presenilin 1 (PSEN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC200Ra01 Polyclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
MAC200Ra21 Monoclonal Antibody to Presenilin 1 (PSEN1) WB; IHC; ICC; IP.
Assay Kits SEC200Ra ELISA Kit for Presenilin 1 (PSEN1) Enzyme-linked immunosorbent assay for Antigen Detection.
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