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Desmoglein 2 (DSG2)

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ARVC10; ARVD10; CDHF5; HDGC; Cadherin family member 5

Desmoglein 2 (DSG2)
CCC C202
HGNC 3049
MGI 1196466
PubMed 24166502
RGD 1311143
UniProt Q14126
Wiki Desmoglein_2
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18.
Desmoglein-2 is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC202Hu01 Recombinant Desmoglein 2 (DSG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC202Hu01 Polyclonal Antibody to Desmoglein 2 (DSG2) WB; IHC; ICC; IP.
MAC202Hu22 Monoclonal Antibody to Desmoglein 2 (DSG2) WB; IHC; ICC; IP.
Assay Kits SEC202Hu ELISA Kit for Desmoglein 2 (DSG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmoglein 2 (DSG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmoglein 2 (DSG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmoglein 2 (DSG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmoglein 2 (DSG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmoglein 2 (DSG2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmoglein 2 (DSG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmoglein 2 (DSG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmoglein 2 (DSG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmoglein 2 (DSG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmoglein 2 (DSG2) ELISA Kit Customized Service Offer
  1. "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins."Exp. Cell Res. 211:391-399(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene."Eur. J. Cell Biol. 55:200-208(1991) [PubMed] [Europe PMC] [Abstract]
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  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Solution structure of the first cadherin domain from human desmoglein-2."Submitted (OCT-2007) to the PDB data bank
  18. "DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy."Am. J. Hum. Genet. 79:136-142(2006) [PubMed] [Europe PMC] [Abstract]
  19. "A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy."Mol. Genet. Metab. 95:74-80(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]