Ribosomal Protein L10 (RPL10)

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RP-L10; NOV; QM; 60S Ribosomal Protein L10; Laminin receptor homolog; Tumor suppressor QM

Ribosomal Protein L10 (RPL10)
60S ribosomal protein L10 is a protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ribosomal Protein L10 (RPL10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ribosomal Protein L10 (RPL10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ribosomal Protein L10 (RPL10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ribosomal Protein L10 (RPL10)CLIA Kit Customized Service Offer
n/aELISA Kit for Ribosomal Protein L10 (RPL10)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ribosomal Protein L10 (RPL10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ribosomal Protein L10 (RPL10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ribosomal Protein L10 (RPL10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ribosomal Protein L10 (RPL10)CLIA Kit Customized Service Offer
n/aELISA Kit for Ribosomal Protein L10 (RPL10)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Ribosomal Protein L10 (RPL10)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Ribosomal Protein L10 (RPL10)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Ribosomal Protein L10 (RPL10)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Ribosomal Protein L10 (RPL10)CLIA Kit Customized Service Offer
n/aELISA Kit for Ribosomal Protein L10 (RPL10)ELISA Kit Customized Service Offer
  1. "The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells."Nucleic Acids Res. 19:5763-5769(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a new gene in the human Xq28 region."Hum. Mol. Genet. 1:269-273(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28."Hum. Mol. Genet. 1:529-533(1992) [PubMed] [Europe PMC] [Abstract]
  4. "QM, a putative tumor suppressor, regulates proto-oncogene c-Yes."J. Biol. Chem. 277:36489-36498(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer."Cancer Biol. Ther. 5:523-528(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene."Biochem. Biophys. Res. Commun. 184:1165-1172(1992) [PubMed] [Europe PMC] [Abstract]
  10. "A map of 75 human ribosomal protein genes."Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold."J. Mol. Biol. 377:421-430(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism."Mol. Psychiatry 11:1073-1084(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation and expression analyses of the ribosomal protein gene RPL10 in an extended German sample of patients with autism spectrum disorder."Am. J. Med. Genet. A 155:1472-1475(2011) [PubMed] [Europe PMC] [Abstract]