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Profilin 1 (PFN1)

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Epididymis tissue protein Li 184a

Profilin 1 (PFN1)
CCC C233
HGNC 8881
MGI 97549
PubMed 23331014
RGD 621825
UniProt P07737
Wiki Profilin_1

Profilin-1 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.

Profilin is a ubiquitous 12- to 15-kD protein which inhibits the polymerization of actin. It is thought to function by complexing with unpolymerized actin in vivo. Dissociation of the profilin-actin complex is caused by binding of phosphatidylinositol 4,5-bisphosphate to profilin. Ampe et al. (1988) described the amino acid sequence of human platelet profilin and found it to have 95% homology to the sequence of calf spleen profilin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC233Hu01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC233Hu01 Polyclonal Antibody to Profilin 1 (PFN1) WB
MAC233Hu22 Monoclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
Assay Kits SEC233Hu ELISA Kit for Profilin 1 (PFN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC233Mu01 Recombinant Profilin 1 (PFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC233Mu01 Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IP.
LAC233Mu81 FITC-Linked Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC; IF.
LAC233Mu71 Biotin-Linked Polyclonal Antibody to Profilin 1 (PFN1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Profilin 1 (PFN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Profilin 1 (PFN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Profilin 1 (PFN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Profilin 1 (PFN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Profilin 1 (PFN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Profilin 1 (PFN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Profilin 1 (PFN1) ELISA Kit Customized Service Offer
  1. "Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis."J. Biol. Chem. 263:5910-5915(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence."FEBS Lett. 228:17-21(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Distinct biochemical characteristics of the two human profilin isoforms."Eur. J. Biochem. 229:621-628(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes."EMBO J. 22:5928-5940(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation."Mol. Cell. Biol. 28:5196-5208(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern."Biochemistry 32:13818-13829(1993) [PubMed] [Europe PMC] [Abstract]