≡

5-Hydroxytryptamine Receptor 1A (HTR1A)

[Edit]

5HTR1A; 5HTR1-A; 5-HTR1-A; ADRB2RL1; ADRBRL1; Serotonin Receptor 1A

5-Hydroxytryptamine Receptor 1A (HTR1A)
CCC C271
HGNC 5286
MGI 96273
PubMed 19124686
RGD 2845
UniProt P08908
Wiki HTR1A
The receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxtryptamine, 5-HT). It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus in high densities, while low amounts also exist in the basal ganglia and thalamus. The 5-HT1A receptors in the raphe nucleus are largely somatodendritic autoreceptors. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC271Hu01 Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) Positive Control; Immunogen; SDS-PAGE; WB.
RPC271Hu02 Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC271Hu01 Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) WB; IHC; ICC; IP.
MAC271Hu21 Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) WB; IHC; ICC; IP.
Assay Kits SEC271Hu ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Hydroxytryptamine Receptor 1A (HTR1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A (HTR1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Hydroxytryptamine Receptor 1A (HTR1A) ELISA Kit Customized Service Offer
  1. "An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."Nature 329:75-79(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Human-specific amino acid changes found in 103 protein-coding genes."Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."Nucleic Acids Res. 19:7155-7160(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."J. Immunol. 151:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]
  6. "The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."Nature 335:358-360(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors."J. Pharmacol. Exp. Ther. 268:1098-1106(1994) [PubMed] [Europe PMC] [Abstract]
  8. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Serotonin receptors."Chem. Rev. 108:1614-1641(2008) [PubMed] [Europe PMC] [Abstract]
  10. "5-HT1A receptor-regulated signal transduction pathways in brain."Cell. Signal. 22:1406-1412(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Serotonin receptors - from molecular biology to clinical applications."Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene."Hum. Mutat. 33:209-217(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Role of glycosphingolipids in the function of human serotonin(1)A receptors."J. Neurochem. 123:716-724(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."J. Biol. Chem. 288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed] [Europe PMC] [Abstract]
  16. "Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."Am. J. Med. Genet. 81:434-439(1998) [PubMed] [Europe PMC] [Abstract]