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Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7)

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CHR-NA7; CHRN-A7; N-AChRA7; NAChRA7; N-AChR-A7; Neuronal Acetylcholine Receptor Alpha 7

Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7)
CCC C305
HGNC 1960
MGI 99779
PubMed 11803513
RGD 2348
UniProt P36544
Wiki CHRNA7
Neuronal acetylcholine receptor subunit alpha-7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC305Hu01 Recombinant Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Positive Control; Immunogen; SDS-PAGE; WB.
RPC305Hu02 Recombinant Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC305Hu01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) WB; IHC; ICC; IP.
MAC305Hu21 Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) WB; IHC; ICC; IP.
Assay Kits SEC305Hu ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC305Ra01 Recombinant Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC305Ra01 Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) WB; IHC; ICC; IP.
Assay Kits SEC305Ra ELISA Kit for Cholinergic Receptor, Nicotinic, Alpha 7 (CHRNa7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."Mol. Pharmacol. 45:546-554(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."Drug Dev. Res. 30:252-256(1993)
  8. "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."Genomics 19:379-381(1994) [PubMed] [Europe PMC] [Abstract]
  9. "A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."Genomics 79:197-209(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."J. Biol. Chem. 280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
  12. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]